ADR1 DNA-binding transcription factor ADR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADR1
Official Full Name: DNA-binding transcription factor ADR1
Primary source: SGD:S000002624
Locus tag: YDR216W
See related: AllianceGenome:SGD:S000002624; FungiDB:YDR216W; VEuPathDB:YDR216W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II general transcription initiation factor binding activity; and transcription coactivator activity. Involved in several processes, including cellular response to ethanol; positive regulation of catabolic process; and positive regulation of peroxisome organization. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ADR1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (895035..899006)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Residues outside the canonical binding 14-3-3 motif are important for interaction with Bmh1.
Title: Binding and transcriptional regulation by 14-3-3 (Bmh) proteins requires residues outside of the canonical motif.
Bmh1 and Bmh2 inhibit transcription by binding to Adr1 at promoters that contain a preinitiation complex, demonstrating that Bmh-mediated inhibition is not due to nuclear exclusion, inhibition of DNA binding, or RNA polymerase II (Pol II) recruitment.
Title: 14-3-3 (Bmh) proteins regulate combinatorial transcription following RNA polymerase II recruitment by binding at Adr1-dependent promoters in Saccharomyces cerevisiae.
Data indicate that Oaf1p, Pip2p and Adr1p are required for the initial binding of Oaf3p before oleate induction.
Title: Role of the repressor Oaf3p in the recruitment of transcription factors and chromatin dynamics during the oleate response.
there is an important overlap between the targets of Rds2 and Adr1.
Title: Genome-wide location analysis reveals an important overlap between the targets of the yeast transcriptional regulators Rds2 and Adr1.
Data show that Bmh binds to the Snf1-dependent transcription factor Adr1 and inhibits its transcriptional activity.
Title: 14-3-3 (Bmh) proteins inhibit transcription activation by Adr1 through direct binding to its regulatory domain.
Loss of Med14 activity enhances expression of Adr1-dependent genes independently of Snf1.
Title: Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant of Saccharomyces cerevisiae.
Adr1 influenced the transcription levels of ETR1, but it did not alter the abundance of Etr1 protein.
Title: A novel circuit overrides Adr1p control during expression of Saccharomyces cerevisiae 2-trans-enoyl-ACP reductase Etr1p of mitochondrial type 2 fatty acid synthase.
Data show that a nonphosphorylatable Ser230Ala mutant was no longer Snf1 dependent for activation of Adr1-dependent genes and could suppress Cat8 dependence at genes coregulated by Adr1 and Cat8.
Title: Snf1 controls the activity of adr1 through dephosphorylation of Ser230.
over-expression of Adr1 can compensate for loss of Cat8 at many genes in terms of both activation and chromatin remodeling
Title: Adr1 and Cat8 mediate coactivator recruitment and chromatin remodeling at glucose-regulated genes.
ADH2 expression was dependent on these factors with wild-type Adr1
Title: Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables TFIIB-class transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables TFIID-class transcription factor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	HDA more info	PubMed
enables transcription coactivator activity	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ethanol catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription from RNA polymerase II promoter by oleic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-binding transcription factor ADR1

NP_010502.3

Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

895035..899006

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180524.3 → NP_010502.3 TPA: DNA-binding transcription factor ADR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010502.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSJ9, P07248, Q04919

UniProtKB/TrEMBL

A6ZYH1, N1P6V0

Conserved Domains (3) summary

sd00017
Location:106 → 126

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:104 → 126

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:118 → 143

zf-H2C2_2; Zinc-finger double domain