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    TAL1 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851068, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TAL1
    Official Full Name
    sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1
    Primary source
    SGD:S000004346
    Locus tag
    YLR354C
    See related
    AllianceGenome:SGD:S000004346; FungiDB:YLR354C; VEuPathDB:YLR354C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transaldolase activity. Involved in pentose-phosphate shunt. Located in nucleus. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder. Orthologous to human TALDO1 (transaldolase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TAL1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (836350..837357, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Lug1p Neighboring gene Bud8p Neighboring gene ketol-acid reductoisomerase Neighboring gene Atg33p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of the structural gene for yeast transaldolase. Schaaff I, et al. Eur J Biochem, 1990 Mar 30. PMID 2185015
    2. Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase. Miosga T, et al. Yeast, 1993 Nov. PMID 8109173
    3. Mechanism of action of transaldolase. I. Crystalization and properties of yeast enzyme. VENKATARAMAN R, et al. J Biol Chem, 1961 Jul. PMID 13780711
    4. Purification and properties of yeast transaldolase. HORECKER BL, et al. J Biol Chem, 1955 Feb. PMID 14353883
    5. Heterologous expression of transaldolase gene Tal from Saccharomyces cerevisiae in Fusarium oxysporum for enhanced bioethanol production. Fan JX, et al. Appl Biochem Biotechnol, 2011 Aug. PMID 21394668

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transaldolase TAL1 paralogue NQM1 and the transcription factor VHR1 interact haploproficiently and affect yeast stationary phase survival.
      Title: A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance.
    2. characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
      Title: Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transaldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transaldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transaldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1
    NP_013458.1
    • Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has a paralog, NQM1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      836350..837357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182243.1 → NP_013458.1  TPA: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013458.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYZ2, P15019
      UniProtKB/TrEMBL
      A7A1N2, B3RHM3, B5VNP4, C7GRX9, C8ZDW1, G2WJH2, N1NZP0
      Conserved Domains (1) summary
      TIGR00874
      Location:14 → 333
      talAB; transaldolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15019.4

    Gene LinkOut

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