RTT109 H3 histone acetyltransferase RTT109 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RTT109
Official Full Name: H3 histone acetyltransferase RTT109
Primary source: SGD:S000003925
Locus tag: YLL002W
See related: AllianceGenome:SGD:S000003925; FungiDB:YLL002W; VEuPathDB:YLL002W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: KAT11; KIM2; REM50
Summary: Enables histone H3 acetyltransferase activity. Involved in DNA metabolic process; regulation of nucleobase-containing compound metabolic process; and retrotransposon silencing. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RTT109 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (146291..147601)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability.
Title: A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability.
Rtt109 promotes nucleosome replacement ahead of the replication fork.
Title: Rtt109 promotes nucleosome replacement ahead of the replication fork.
Rtt109 slows replication speed by histone N-terminal acetylation.
Title: Rtt109 slows replication speed by histone N-terminal acetylation.
Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4.
Title: Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4.
Data show that H3 histone acetyltransferase RTT109 (Rtt109) C-terminus interacts directly with nucleosome assembly factor ASF1 (Asf1) and the structural basis of this interaction.
Title: Structural characterization of the Asf1-Rtt109 interaction and its role in histone acetylation.
This replication-guided H3K9ac was fully dependent on the acetyltransferase Rtt109, while expression-guided H3K9ac was deposited by Gcn5. Further, topoisomerase depletion intensified H3K9ac in front of the replication fork and in sites where RNA polymerase II was trapped, suggesting supercoiling stresses trigger H3K9 acetylation.
Title: Chromatin dynamics during DNA replication.
The absence of RTT109 enhanced resistance to 5.5 g L(-1) acetic acid, which was indicated by improved growth of RTT109Delta mutant compared with that of the wild-type BY4741 strain.
Title: Absence of Rtt109p, a fungal-specific histone acetyltransferase, results in improved acetic acid tolerance of Saccharomyces cerevisiae.
Vps75 and Asf1 both enhance Rtt109 acetylation for H3/H4
Title: Utilizing targeted mass spectrometry to demonstrate Asf1-dependent increases in residue specificity for Rtt109-Vps75 mediated histone acetylation.
Lys290 in Rtt109 is required in vivo for Vps75 to enhance the activity of the histone acetyltransferase.
Title: The carboxyl terminus of Rtt109 functions in chaperone control of histone acetylation.
Rtt109-Vps75 preferentially acetylates H3 K9 and K23
Title: Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables histone H3 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3 acetyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables histone H3 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K56 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in maintenance of rDNA	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication-born double-strand break repair via sister chromatid exchange	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrotransposon silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: H3 histone acetyltransferase RTT109

NP_013099.1

EC 2.3.1.48

Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

146291..147601

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181822.1 → NP_013099.1 TPA: H3 histone acetyltransferase RTT109 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013099.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VY01, Q07794

UniProtKB/TrEMBL

A7A0Q4, B3LTG4, C7GPF9, C8ZCX1, G2WIJ3, N1P005

Conserved Domains (1) summary

COG5087
Location:3 → 432

RTT109; Uncharacterized conserved protein [Function unknown]