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    RBS1 Rbs1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851338, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RBS1
    Official Full Name
    Rbs1p
    Primary source
    SGD:S000002348
    Locus tag
    YDL189W
    See related
    AllianceGenome:SGD:S000002348; FungiDB:YDL189W; VEuPathDB:YDL189W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA 5'-UTR binding activity. Involved in RNA polymerase III assembly and galactose metabolic process. Located in cytoplasm. Is active in nucleus. Orthologous to human R3HDM2 (R3H domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RBS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (122216..123589)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L35A Neighboring gene ubiquitin-ubiquitin ligase UFD2 Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH22 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rbs1 protein, involved in RNA polymerase III complex assembly in the yeast Saccharomyces cerevisiae, induces a Gcn4 response and forms aggregates when overproduced. Rudzińska I, et al. Gene, 2022 Jan 30. PMID 34688816
    2. Coupling of RNA polymerase III assembly to cell cycle progression in Saccharomyces cerevisiae. Płonka M, et al. Cell Cycle, 2019 Feb. PMID 30760101, Free PMC Article
    3. Reprogramming mRNA Expression in Response to Defect in RNA Polymerase III Assembly in the Yeast Saccharomyces cerevisiae. Rudzińska I, et al. Int J Mol Sci, 2021 Jul 7. PMID 34298922, Free PMC Article
    4. The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase. Cieśla M, et al. Nucleic Acids Res, 2020 Dec 2. PMID 33231687, Free PMC Article
    5. Rbs1, a new protein implicated in RNA polymerase III biogenesis in yeast Saccharomyces cerevisiae. Cieśla M, et al. Mol Cell Biol, 2015 Apr. PMID 25605335, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rbs1 protein, involved in RNA polymerase III complex assembly in the yeast Saccharomyces cerevisiae, induces a Gcn4 response and forms aggregates when overproduced.
      Title: Rbs1 protein, involved in RNA polymerase III complex assembly in the yeast Saccharomyces cerevisiae, induces a Gcn4 response and forms aggregates when overproduced.
    2. The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase.
      Title: The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase.
    3. Rbs1 physically interacts with a subset of Pol III subunits, AC19, AC40, and ABC27/Rpb5. Rbs1 binds to the Pol III complex or subcomplex and facilitates its translocation to the nucleus.
      Title: Rbs1, a new protein implicated in RNA polymerase III biogenesis in yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rbs1p
    NP_010092.2
    • Protein involved in assembly of the RNA Pol III complex; high copy suppressor of Pol III assembly mutation and psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; physically interacts with Pol III; proposed to bind single-stranded nucleic acids via its R3H domain; capable of forming the prion [VTS1+]

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      122216..123589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180249.1 → NP_010092.2  TPA: Rbs1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010092.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRG4, Q05672, Q06896, Q07619, Q870H2
      UniProtKB/TrEMBL
      G2WBX7
      Conserved Domains (1) summary
      cd02642
      Location:25 → 85
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05672.1

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