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    QRI1 UDP-N-acetylglucosamine diphosphorylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851455, updated on 2-Nov-2024

    Summary

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    Official Symbol
    QRI1
    Official Full Name
    UDP-N-acetylglucosamine diphosphorylase
    Primary source
    SGD:S000002261
    Locus tag
    YDL103C
    See related
    AllianceGenome:SGD:S000002261; FungiDB:YDL103C; VEuPathDB:YDL103C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    UAP1
    Summary
    Enables UDP-N-acetylglucosamine diphosphorylase activity. Involved in UDP-N-acetylglucosamine biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1) and UAP1L1 (UDP-N-acetylglucosamine pyrophosphorylase 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See QRI1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (275148..276581, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Smc5-Smc6 complex subunit NSE4 Neighboring gene putative N(6)-L-threonylcarbamoyladenine synthase Neighboring gene DNA-directed DNA polymerase delta POL3 Neighboring gene serine/threonine protein kinase DUN1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of the PHO2-POL3 (CDC2) region of chromosome IV of Saccharomyces cerevisiae. Simon M, et al. Yeast, 1994 Dec. PMID 7725801
    2. RNA-binding proteins that inhibit RNA virus infection. Zhu J, et al. Proc Natl Acad Sci U S A, 2007 Feb 27. PMID 17360619, Free PMC Article
    3. Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis. Mio T, et al. J Biol Chem, 1999 Jan 1. PMID 9867860
    4. Yeast KEOPS complex regulates telomere length independently of its t(6)A modification function. Liu YY, et al. J Genet Genomics, 2018 May 20. PMID 29804714
    5. The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae. Alme EB, et al. PLoS Genet, 2020 Jun. PMID 32579556, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine diphosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine diphosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine diphosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine diphosphorylase
    NP_010180.1
    • UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      275148..276581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180162.1 → NP_010180.1  TPA: UDP-N-acetylglucosamine diphosphorylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010180.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRP7, P43123
      UniProtKB/TrEMBL
      G2WC60
      Conserved Domains (1) summary
      COG4284
      Location:1 → 477
      QRI1; UDP-N-acetylglucosamine pyrophosphorylase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43123.1

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