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    srsf6a serine and arginine rich splicing factor 6a [ Danio rerio (zebrafish) ]

    Gene ID: 406775, updated on 2-Nov-2024

    Summary

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    Official Symbol
    srsf6aprovided by ZNC
    Official Full Name
    serine and arginine rich splicing factor 6aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2824
    See related
    Ensembl:ENSDARG00000013729 AllianceGenome:ZFIN:ZDB-GENE-040426-2824
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sfrs6a; fa12h12; zgc:63770; wu:fa12h12; wu:fa13e06
    Summary
    Predicted to enable mRNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to human SRSF6 (serine and arginine rich splicing factor 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See srsf6a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (4260465..4271984)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (4321550..4333083)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene zgc:113278 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 5b Neighboring gene si:ch211-10d23.5 Neighboring gene L3MBTL histone methyl-lysine binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish. Ren F, et al. Commun Biol, 2020 Mar 3. PMID 32127635, Free PMC Article
    2. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine and arginine rich splicing factor 6a
    Names
    serine/arginine-rich splicing factor 6a
    splicing factor, arginine/serine-rich 6a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213466.1 → NP_998631.1  serine and arginine rich splicing factor 6a

      See identical proteins and their annotated locations for NP_998631.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055238
      UniProtKB/TrEMBL
      Q7SXU9
      Related
      ENSDARP00000094522.3, ENSDART00000103747.5
      Conserved Domains (2) summary
      cd12600
      Location:82 → 153
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cl17169
      Location:3 → 62
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      4260465..4271984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161922.5 → XP_005161979.1  serine and arginine rich splicing factor 6a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B8T5
      Conserved Domains (3) summary
      COG0724
      Location:3 → 137
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12600
      Location:135 → 206
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cl17169
      Location:3 → 72
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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