cct2 chaperonin containing TCP1, subunit 2 (beta) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cct2provided by ZNC
Official Full Name: chaperonin containing TCP1, subunit 2 (beta)provided by ZNC
Primary source: ZFIN:ZDB-GENE-020419-6
See related: Ensembl:ENSDARG00000104674 AllianceGenome:ZFIN:ZDB-GENE-020419-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa26a01; fc58a11; CHUNP6883; wu:fa26a01; wu:fc58a11
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent protein folding chaperone. Acts upstream of or within Kupffer's vesicle development and melanosome transport. Predicted to be located in cytosol. Predicted to be part of chaperonin-containing T-complex. Orthologous to human CCT2 (chaperonin containing TCP1 subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1, chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (78022546..78026284, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (76623606..76624991)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_008805374.1 (656..4394)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The retinal pathology observed in the homozygous cct2-L394H-7del mutants resembles the retinal pathology of human leber congenital amaurosis (LCA) patients.
Title: Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chaperonin-containing T-complex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-complex protein 1 subunit beta

Names: subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201455.1 → NP_958863.1 T-complex protein 1 subunit beta

See identical proteins and their annotated locations for NP_958863.1

Status: PROVISIONAL

Source sequence(s)

BC059558

UniProtKB/TrEMBL

Q6PBW6

Related

ENSDARP00000136096.1, ENSDART00000168273.2

Conserved Domains (2) summary

PTZ00212
Location:7 → 530

PTZ00212; T-complex protein 1 subunit beta; Provisional

cd03336
Location:11 → 527

TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...