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    ctdspla CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a [ Danio rerio (zebrafish) ]

    Gene ID: 751737, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ctdsplaprovided by ZNC
    Official Full Name
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-333
    See related
    Ensembl:ENSDARG00000071673 AllianceGenome:ZFIN:ZDB-GENE-060825-333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fj98d02; zgc:153196
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Orthologous to human CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ctdspla in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20450021..20531813, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20305608..20387394, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene phospholipase C, delta 1a Neighboring gene villin-like Neighboring gene uncharacterized LOC137489234 Neighboring gene microRNA 26a-3 Neighboring gene glycyl-tRNA synthetase 1 Neighboring gene hedgehog acyltransferase like, b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153196

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a
    NP_001038912.2
    XP_005162767.1
    XP_068073219.1
    XP_068073221.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045447.2 → NP_001038912.2  CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a

      Status: VALIDATED

      Source sequence(s)
      BC122182, CN836983, CO914203, EB864555, EB937092
      UniProtKB/TrEMBL
      A0A8M1NAQ0, Q0P4B2
      Related
      ENSDARP00000083861.5, ENSDART00000089428.7
      Conserved Domains (2) summary
      COG5190
      Location:68 → 261
      FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]
      TIGR02251
      Location:95 → 254
      HIF-SF_euk; Dullard-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      20450021..20531813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217120.1 → XP_068073221.1  CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a isoform X2

    2. XM_005162710.5 → XP_005162767.1  CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a isoform X3

      UniProtKB/TrEMBL
      A0A0R4IC10, A0A8M2B9P9
      Related
      ENSDARP00000130556.1, ENSDART00000172298.2
      Conserved Domains (3) summary
      COG5190
      Location:95 → 272
      FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]
      TIGR02251
      Location:106 → 265
      HIF-SF_euk; Dullard-like phosphatase domain
      pfam16642
      Location:14 → 92
      KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

    3. XM_068217118.1 → XP_068073219.1  CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a isoform X1

    Nucleotide Protein
    Heading Accession and Version

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