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    manba mannosidase, beta A, lysosomal [ Danio rerio (zebrafish) ]

    Gene ID: 393128, updated on 2-Nov-2024

    Summary

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    Official Symbol
    manbaprovided by ZNC
    Official Full Name
    mannosidase, beta A, lysosomalprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-721
    See related
    Ensembl:ENSDARG00000008238 AllianceGenome:ZFIN:ZDB-GENE-040426-721
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55493; zgc:76896
    Summary
    Predicted to enable beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in extracellular region and lysosome. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See manba in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (11719703..11744098, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (11587228..11611623, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8 Neighboring gene solute carrier family 39 member 8 Neighboring gene ubiquitin-conjugating enzyme E2D 3 Neighboring gene zmp:0000000662

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease. Ko YA, et al. Am J Hum Genet, 2017 Jun 1. PMID 28575649, Free PMC Article
    2. Proteome Profile of Myelin in the Zebrafish Brain. Siems SB, et al. Front Cell Dev Biol, 2021. PMID 33898427, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55493

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables beta-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-mannosidase
    NP_956453.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200159.1 → NP_956453.1  beta-mannosidase precursor

      See identical proteins and their annotated locations for NP_956453.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045360
      UniProtKB/TrEMBL
      Q7ZVY7
      Related
      ENSDARP00000073766.5, ENSDART00000079310.8
      Conserved Domains (4) summary
      COG3250
      Location:38 → 858
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
      pfam00703
      Location:237 → 343
      Glyco_hydro_2; Glycosyl hydrolases family 2
      pfam02837
      Location:94 → 163
      Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
      cl23725
      Location:362 → 508
      Glyco_hydro_1; Glycosyl hydrolase family 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      11719703..11744098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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