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    cpt1b carnitine palmitoyltransferase 1B (muscle) [ Danio rerio (zebrafish) ]

    Gene ID: 449677, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cpt1bprovided by ZNC
    Official Full Name
    carnitine palmitoyltransferase 1B (muscle)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-9
    See related
    Ensembl:ENSDARG00000058285 AllianceGenome:ZFIN:ZDB-GENE-041010-9
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cpt1al; zgc:103709
    Summary
    Predicted to enable carnitine O-palmitoyltransferase activity. Acts upstream of or within energy homeostasis; response to (R)-carnitine; and response to bacterium. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adipose tissue; digestive system; eye; female organism; and integument. Orthologous to human CPT1B (carnitine palmitoyltransferase 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cpt1b in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (8346914..8367561)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (8388895..8409542)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene choline kinase beta Neighboring gene kelch repeat and BTB domain-containing protein 13 Neighboring gene selenophosphate synthetase 1 Neighboring gene BEN domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Alteration and the Function of Intestinal Microbiota in High-Fat-Diet- or Genetics-Induced Lipid Accumulation. Qiao F, et al. Front Microbiol, 2021. PMID 34603270, Free PMC Article
    2. Nonmonotonic response of type 2 diabetes by low concentration organochlorine pesticide mixture: Findings from multi-omics in zebrafish. Lee H, et al. J Hazard Mater, 2021 Aug 15. PMID 34492873
    3. In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut. Rawls JF, et al. Proc Natl Acad Sci U S A, 2007 May 1. PMID 17456593, Free PMC Article
    4. The evolution of pepsinogen C genes in vertebrates: duplication, loss and functional diversification. Castro LF, et al. PLoS One, 2012. PMID 22427897, Free PMC Article
    5. Identification and Characterization of Carnitine Palmitoyltransferase 1 (cpt 1) Genes in Nile Tilapia, Oreochromis niloticus. Bayır M, et al. Evol Bioinform Online, 2020. PMID 32231427, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to (R)-carnitine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carnitine O-palmitoyltransferase 1, muscle isoform
    Names
    carnitine palmitoyltransferase 1A like
    NP_001315121.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328192.1 → NP_001315121.1  carnitine O-palmitoyltransferase 1, muscle isoform

      Status: VALIDATED

      Source sequence(s)
      BX276107, CD605320, EH477141, EH509285
      UniProtKB/TrEMBL
      A0A8M1P3M1, F6P7Z9, Q1LXU0
      Related
      ENSDARP00000077856.5, ENSDART00000083421.7
      Conserved Domains (2) summary
      pfam00755
      Location:171 → 760
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 46
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      8346914..8367561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005940.1: Suppressed sequence

      Description
      NM_001005940.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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