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    tmpoa thymopoietin a [ Danio rerio (zebrafish) ]

    Gene ID: 352907, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tmpoaprovided by ZNC
    Official Full Name
    thymopoietin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6003
    See related
    Ensembl:ENSDARG00000007315 AllianceGenome:ZFIN:ZDB-GENE-030131-6003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    LAP2; tmpo; wu:fc26f12; wu:fd21f02; wu:fi29h05; etID53005.4
    Summary
    Enables chromatin binding activity. Acts upstream of or within mitotic nuclear membrane reassembly. Located in condensed chromosome and nuclear outer membrane-endoplasmic reticulum membrane network. Orthologous to human TMPO (thymopoietin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See tmpoa in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (16857722..16876336, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (16868746..16887360, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase Ba Neighboring gene solute carrier family 25 member 3a Neighboring gene serine/threonine kinase receptor associated protein Neighboring gene ethanolamine kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The lamina-associated polypeptide 2 (LAP2) genes of zebrafish and chicken: no LAP2alpha isoform is synthesised by non-mammalian vertebrates. Prüfert K, et al. Eur J Cell Biol, 2004 Aug. PMID 15506564
    2. Lamina-associated polypeptide 2 (LAP2) expression in fish and amphibians. Del-Pino EM, et al. Int J Dev Biol, 2002 Mar. PMID 11934151
    3. The lamina-associated polypeptide 2 (LAP2) isoforms beta, gamma and omega of zebrafish: developmental expression and behavior during the cell cycle. Schoft VK, et al. J Cell Sci, 2003 Jun 15. PMID 12734396
    4. Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons. Zada D, et al. Nat Commun, 2019 Mar 5. PMID 30837464, Free PMC Article
    5. Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches. De Wit M, et al. Chemosphere, 2008 Dec. PMID 18976794

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitotic nuclear membrane reassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thymopoietin a
    Names
    lamina-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328563.1 → NP_001315492.1  thymopoietin a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BX649476
      UniProtKB/TrEMBL
      A0A8M1P534, Q5RGX4
      Related
      ENSDARP00000021537.7, ENSDART00000016690.8

    2. NM_001328564.1 → NP_001315493.1  thymopoietin a isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX649476
      UniProtKB/TrEMBL
      A0A2R8Q454, A0A8M1PA69
      Related
      ENSDARP00000147840.1, ENSDART00000185974.1

    3. NM_001328565.1 → NP_001315494.1  thymopoietin a isoform 4

      Status: VALIDATED

      Source sequence(s)
      BX649476
      UniProtKB/TrEMBL
      A0A8M1P434, Q5RGX2
      Related
      ENSDARP00000044004.4, ENSDART00000044005.6
      Conserved Domains (2) summary
      cd12940
      Location:94 → 135
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:3 → 49
      Thymopoietin; Thymopoietin protein

    4. NM_180968.3 → NP_851299.1  thymopoietin a isoform 2

      See identical proteins and their annotated locations for NP_851299.1

      Status: VALIDATED

      Source sequence(s)
      BX649476
      UniProtKB/TrEMBL
      B2GTE5, F6NVE0, Q7ZTV0
      Related
      ENSDARP00000108241.2, ENSDART00000125762.4
      Conserved Domains (2) summary
      cd12940
      Location:94 → 135
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:3 → 49
      Thymopoietin; Thymopoietin protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      16857722..16876336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219530.1 → XP_068075631.1  thymopoietin a isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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