Akr7a2 aldo-keto reductase family 7, member A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akr7a2provided by RGD
Official Full Name: aldo-keto reductase family 7, member A2provided by RGD
Primary source: RGD:620311
See related: EnsemblRapid:ENSRNOG00000017780 AllianceGenome:RGD:620311
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aiar
Summary: Enables aldose reductase (NADPH) activity. Predicted to be involved in daunorubicin metabolic process and doxorubicin metabolic process. Located in nuclear envelope. Orthologous to human AKR7A2 (aldo-keto reductase family 7 member A2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Kidney (RPKM 1598.8), Liver (RPKM 462.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (156835589..156844127)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (151552375..151560914)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (157759448..157768473)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Afar (e-PCR), detects polymorphism
- UniSTS:141046

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldo-keto reductase (NADPH) activity	NAS Non-traceable Author Statement more info	PubMed
enables aldo-keto reductase (NADPH) activity	TAS Traceable Author Statement more info	PubMed
enables aldose reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables phenanthrene-9,10-epoxide hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aflatoxin B1 aldehyde reductase member 2

Names: SSA reductase; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); rAFAR2; succinic semialdehyde reductase

NP_599234.1

EC 1.1.1.n11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134407.2 → NP_599234.1 aflatoxin B1 aldehyde reductase member 2

See identical proteins and their annotated locations for NP_599234.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q6P765, Q8CG45, Q8K435, Q9JM82

UniProtKB/TrEMBL

A0A0G2K3V2, A6ITL3

Related

ENSRNOP00000072789.3, ENSRNOT00000083629.3

Conserved Domains (2) summary

cd06660
Location:21 → 325

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

COG0667
Location:21 → 334

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]