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    Ccdc125 coiled-coil domain containing 125 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499518, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Ccdc125provided by RGD
    Official Full Name
    coiled-coil domain containing 125provided by RGD
    Primary source
    RGD:1561673
    See related
    EnsemblRapid:ENSRNOG00000027410 AllianceGenome:RGD:1561673
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561673
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in activation of GTPase activity; negative regulation of Rho protein signal transduction; and negative regulation of cell motility. Predicted to be active in cytoplasm. Orthologous to human CCDC125 (coiled-coil domain containing 125). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 49.1), Lung (RPKM 48.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc125 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33542916..33568501)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31809120..31835538)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30685845..30726617)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102557393 Neighboring gene MARVEL domain containing 2 Neighboring gene RAD17 checkpoint clamp loader component Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene cyclin-dependent kinase 7 Neighboring gene KtI12 chromatin associated, pseudogene 1 Neighboring gene alpha-ketoglutarate dehydrogenase subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase. Araya N, et al. Int J Mol Med, 2009 Nov. PMID 19787194
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 125

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134761.3 → NP_001128233.1  coiled-coil domain-containing protein 125

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZSW7, F1LRT4
      Conserved Domains (1) summary
      COG1196
      Location:101 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      33542916..33568501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102827.2 → XP_038958755.1  coiled-coil domain-containing protein 125 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSW7, F1LRT4
      Related
      ENSRNOP00000035653.4, ENSRNOT00000031385.7
      Conserved Domains (1) summary
      COG1196
      Location:101 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_039102828.2 → XP_038958756.1  coiled-coil domain-containing protein 125 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSW7, F1LRT4
      Conserved Domains (1) summary
      COG1196
      Location:101 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_039102831.2 → XP_038958759.1  coiled-coil domain-containing protein 125 isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:101 → 268
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_039102829.2 → XP_038958757.1  coiled-coil domain-containing protein 125 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSW7, F1LRT4
      Conserved Domains (1) summary
      COG1196
      Location:101 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_063282346.1 → XP_063138416.1  coiled-coil domain-containing protein 125 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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