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    Hao2 hydroxyacid oxidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 56185, updated on 2-Nov-2024

    Summary

    Official Symbol
    Hao2provided by MGI
    Official Full Name
    hydroxyacid oxidase 2provided by MGI
    Primary source
    MGI:MGI:96012
    See related
    Ensembl:ENSMUSG00000027870 AllianceGenome:MGI:96012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hao3; Hao-2; Haox3
    Summary
    Predicted to enable (S)-2-hydroxy-acid oxidase activity; FMN binding activity; and identical protein binding activity. Predicted to be involved in fatty acid alpha-oxidation and mandelate metabolic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland; genitourinary system; and nervous system. Orthologous to human HAO2 (hydroxyacid oxidase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 147.3), colon adult (RPKM 32.6) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Hao2 in Genome Data Viewer
    Location:
    3 F2.2; 3 42.9 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98781835..98802692, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98874519..98895376, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene 14-3-3 protein eta pseudogene Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Neighboring gene predicted gene, 31880 Neighboring gene predicted gene 12440

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (S)-2-hydroxy-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables (S)-2-hydroxy-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables (S)-2-hydroxy-acid oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mandelate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    2-Hydroxyacid oxidase 2
    Names
    (S)-2-hydroxy-acid oxidase, peroxisomal
    HAOX2
    hydroxyacid oxidase (glycolate oxidase) 3
    hydroxyacid oxidase 2, kidney
    medium chain alpha-hydroxy acid oxidase
    medium-chain 2-hydroxy acid oxidase HAOX3
    medium-chain L-2-hydroxy acid oxidase
    NP_062418.3
    XP_011238471.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019545.4NP_062418.3  2-Hydroxyacid oxidase 2

      See identical proteins and their annotated locations for NP_062418.3

      Status: VALIDATED

      Source sequence(s)
      AF272947, AL671965, BB746253
      Consensus CDS
      CCDS17671.1
      UniProtKB/Swiss-Prot
      Q9JHS7, Q9JI00, Q9NYQ2
      UniProtKB/TrEMBL
      Q3UNU6, Q8JZR9, Q9D2W7
      Related
      ENSMUSP00000029464.8, ENSMUST00000029464.9
      Conserved Domains (1) summary
      pfam01070
      Location:14349
      FMN_dh; FMN-dependent dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      98781835..98802692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240169.3XP_011238471.1  2-Hydroxyacid oxidase 2 isoform X1

      See identical proteins and their annotated locations for XP_011238471.1

      UniProtKB/Swiss-Prot
      Q9JHS7, Q9JI00, Q9NYQ2
      UniProtKB/TrEMBL
      Q3UNU6, Q8JZR9, Q9D2W7
      Conserved Domains (1) summary
      pfam01070
      Location:14349
      FMN_dh; FMN-dependent dehydrogenase