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    Dhdh dihydrodiol dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 71755, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dhdhprovided by MGI
    Official Full Name
    dihydrodiol dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:1919005
    See related
    Ensembl:ENSMUSG00000011382 AllianceGenome:MGI:1919005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xld1; Xld-1; 1300018L09Rik; B830008H07Rik
    Summary
    Enables D-xylose 1-dehydrogenase (NADP+) activity. Acts upstream of or within D-xylose catabolic process. Is expressed in nervous system and respiratory system. Orthologous to human DHDH (dihydrodiol dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 18.6), subcutaneous fat pad adult (RPKM 17.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhdh in Genome Data Viewer
    Location:
    7 B3; 7 29.32 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45122380..45138312, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45472956..45488888, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18840 Neighboring gene ferritin light polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_18841 Neighboring gene BCL2-associated X protein Neighboring gene TUB like protein 2 Neighboring gene nucleobindin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2239 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52781513-52781717 Neighboring gene protein phosphatase 1, regulatory subunit 15A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Xylose dehydrogenase-1, a new gene on mouse chromosome 7. Newton MF, et al. Biochem Genet, 1982 Aug. PMID 6753830
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-xylose 1-dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-xylose 1-dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-xylose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    Names
    D-xylose 1-dehydrogenase
    D-xylose-NADP dehydrogenase
    dihydrodiol dehydrogenase (dimeric)
    dimeric dihydrodiol dehydrogenase
    xylose dehydrogenase 1
    NP_082179.1
    XP_006541262.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027903.4 → NP_082179.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

      See identical proteins and their annotated locations for NP_082179.1

      Status: VALIDATED

      Source sequence(s)
      AC151602
      Consensus CDS
      CCDS21247.1
      UniProtKB/Swiss-Prot
      Q14B09, Q9DBB8
      UniProtKB/TrEMBL
      Q8K0E9
      Related
      ENSMUSP00000011526.5, ENSMUST00000011526.7
      Conserved Domains (2) summary
      COG0673
      Location:1 → 325
      MviM; Predicted dehydrogenase [General function prediction only]
      pfam01408
      Location:3 → 121
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45122380..45138312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541199.4 → XP_006541262.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X1

      UniProtKB/TrEMBL
      Q8K0E9
      Conserved Domains (1) summary
      COG0673
      Location:1 → 368
      MviM; Predicted dehydrogenase [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBB8.1 GenPept UniProtKB/Swiss-Prot:Q9DBB8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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