Lyrm7 LYR motif containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lyrm7provided by MGI
Official Full Name: LYR motif containing 7provided by MGI
Primary source: MGI:MGI:1922780
See related: Ensembl:ENSMUSG00000020268 AllianceGenome:MGI:1922780
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700024C24Rik; 9330147L21Rik
Summary: Predicted to enable protein folding chaperone. Predicted to be involved in cellular respiration and mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 8. Orthologous to human LYRM7 (LYR motif containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 4.6), cortex adult (RPKM 2.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 32.13 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (54717692..54751738, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (54826866..54860921, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular respiration	IEA Inferred from Electronic Annotation more info
involved_in cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex III assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex III assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex III assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: complex III assembly factor LYRM7

Names: LYR motif-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363191.2 → NP_001350120.2 complex III assembly factor LYRM7 isoform 2

Status: VALIDATED

Source sequence(s)

AL954817

Conserved Domains (1) summary

pfam05347
Location:5 → 58

Complex1_LYR; Complex 1 protein (LYR family)
NM_029327.5 → NP_083603.4 complex III assembly factor LYRM7 isoform 1

Status: VALIDATED

Source sequence(s)

AL954817

Consensus CDS

CCDS36154.2

UniProtKB/Swiss-Prot

B7ZDF8, Q9DA03

Related

ENSMUSP00000120778.2, ENSMUST00000144164.9

Conserved Domains (1) summary

pfam05347
Location:5 → 59

Complex1_LYR; Complex 1 protein (LYR family)

RNA

NR_156460.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL954817

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

54717692..54751738 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314815.3 → XP_017170304.1 complex III assembly factor LYRM7 isoform X1

Conserved Domains (1) summary

cd20267
Location:36 → 83

Complex1_LYR_LYRM7; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins