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    Sh2d1a SH2 domain containing 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501502, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sh2d1aprovided by RGD
    Official Full Name
    SH2 domain containing 1Aprovided by RGD
    Primary source
    RGD:1562408
    See related
    EnsemblRapid:ENSRNOG00000080232 AllianceGenome:RGD:1562408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562408
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in natural killer cell activation and negative regulation of T cell receptor signaling pathway. Predicted to act upstream of or within humoral immune response and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 1. Orthologous to human SH2D1A (SH2 domain containing 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 381.6), Spleen (RPKM 89.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh2d1a in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (126239191..126267425)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (121373693..121401923)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (128897053..128925408)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene estrogen receptor binding site associated, antigen, 9, pseudogene 1 Neighboring gene testis-expressed protein 13D-like Neighboring gene teneurin transmembrane protein 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 60S ribosomal protein L23 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SAP is required for generating long-term humoral immunity. Crotty S, et al. Nature, 2003 Jan 16. PMID 12529646
    2. SLAM-associated protein as a potential negative regulator in Trk signaling. Lo KY, et al. J Biol Chem, 2005 Dec 16. PMID 16223723
    3. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Sayos J, et al. Nature, 1998 Oct 1. PMID 9774102
    4. Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Roncagalli R, et al. Nat Immunol, 2005 Oct. PMID 16127454
    5. Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Dong Z, et al. Nat Immunol, 2009 Sep. PMID 19648922

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAP may serve as a negative regulator of Trk receptor activation and downstream signaling
      Title: SLAM-associated protein as a potential negative regulator in Trk signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within humoral immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing protein 1A
    Names
    SH2 domain protein 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109313.3 → NP_001102783.2  SH2 domain-containing protein 1A

      See identical proteins and their annotated locations for NP_001102783.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      B2RZ59
      Related
      ENSRNOP00000098812.1, ENSRNOT00000157081.1
      Conserved Domains (1) summary
      cd10400
      Location:2 → 104
      SH2_SAP1a; Src homology 2 (SH2) domain found in SLAM-associated protein (SAP) 1a

    2. NM_001434335.1 → NP_001421264.1  SH2 domain-containing protein 1A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      126239191..126267425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280196.1 → XP_063136266.1  SH2 domain-containing protein 1A isoform X1

      UniProtKB/Swiss-Prot
      B2RZ59
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RZ59.1 GenPept UniProtKB/Swiss-Prot:B2RZ59

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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