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    FKS3 putative 1,3-beta-D-glucan synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855353, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FKS3
    Official Full Name
    putative 1,3-beta-D-glucan synthase
    Primary source
    SGD:S000004923
    Locus tag
    YMR306W
    See related
    AllianceGenome:SGD:S000004923; FungiDB:YMR306W; VEuPathDB:YMR306W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 1,3-beta-D-glucan synthase activity. Involved in ascospore wall assembly. Located in endoplasmic reticulum and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FKS3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (881159..886516)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease UBP15 Neighboring gene putative family 17 glucosidase Neighboring gene 1,3-beta-glucanosyltransferase GAS1 Neighboring gene Pse1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The FKS family genes cause changes in cell wall morphology resulted in regulation of anti-autolytic ability in Saccharomyces cerevisiae. Wang J, et al. Bioresour Technol, 2018 Feb. PMID 29040859
    2. Homologous subunits of 1,3-beta-glucan synthase are important for spore wall assembly in Saccharomyces cerevisiae. Ishihara S, et al. Eukaryot Cell, 2007 Feb. PMID 17158736, Free PMC Article
    3. A microtiter-based fluorescence assay for (1,3)-beta-glucan synthases. Shedletzky E, et al. Anal Biochem, 1997 Jun 15. PMID 9193713
    4. Cell wall synthesis specific cytocidal effect of Hansenula mrakii toxin-1 on Saccharomyces cerevisiae. Takasuka T, et al. Cell Mol Biol Res, 1995. PMID 8777437
    5. Inhibition of yeast (1,3)-beta-glucan synthase by phospholipase A2 and its reaction products. Ko YT, et al. Biochim Biophys Acta, 1994 Jul 13. PMID 8038192

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1,3-beta-D-glucan synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1,3-beta-D-glucan synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1,3-beta-D-glucan synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in (1->3)-beta-D-glucan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in (1->3)-beta-D-glucan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall polysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 1,3-beta-D-glucan synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative 1,3-beta-D-glucan synthase
    NP_014036.1
    • Protein involved in spore wall assembly; has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      881159..886516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182817.1 → NP_014036.1  TPA: putative 1,3-beta-D-glucan synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014036.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0D3, Q04952
      UniProtKB/TrEMBL
      B3LMJ4, C7GPV7, C8ZFH5, G2WL15, N1NZ80
      Conserved Domains (2) summary
      pfam02364
      Location:694 → 1542
      Glucan_synthase; 1,3-beta-glucan synthase component
      pfam14288
      Location:182 → 290
      FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04952.1

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