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    Tril TLR4 interactor with leucine-rich repeats [ Mus musculus (house mouse) ]

    Gene ID: 66873, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trilprovided by MGI
    Official Full Name
    TLR4 interactor with leucine-rich repeatsprovided by MGI
    Primary source
    MGI:MGI:1914123
    See related
    Ensembl:ENSMUSG00000043496 AllianceGenome:MGI:1914123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0644; 1200009O22Rik
    Summary
    Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in regulation of cytokine production involved in immune response and toll-like receptor 4 signaling pathway. Predicted to be part of lipopolysaccharide receptor complex. Predicted to be active in extracellular matrix and extracellular space. Is expressed in cerebral cortex and heart valve. Orthologous to human TRIL (TLR4 interactor with leucine rich repeats). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See Tril in Genome Data Viewer
    Location:
    6 B3; 6 26.07 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (53792453..53797810, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (53815468..53820825, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57762 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_15934 Neighboring gene predicted gene 16499 Neighboring gene STARR-seq mESC enhancer starr_15935 Neighboring gene STARR-seq mESC enhancer starr_15936 Neighboring gene predicted gene, 22910

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRIL is involved in cytokine production in the brain following Escherichia coli infection. Wochal P, et al. J Immunol, 2014 Aug 15. PMID 25015823, Free PMC Article
    2. TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation. Moura-Assis A, et al. Sci Rep, 2021 Sep 9. PMID 34504172, Free PMC Article
    3. TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. Carpenter S, et al. J Immunol, 2009 Sep 15. PMID 19710467
    4. Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication. Lehoczky JA, et al. Evol Dev, 2004 Nov-Dec. PMID 15509224
    5. RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons. Xiang C, et al. Mol Cell Biol, 2021 Jun 23. PMID 33903225, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation.
      Title: TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation.
    2. these data uncover TRIL as a mediator of innate immune responses within the brain, where it enhances neuronal cytokine responses to infection.
      Title: TRIL is involved in cytokine production in the brain following Escherichia coli infection.
    3. TRIL is a novel component of the TLR4 complex which may have particular relevance for the functional role of TLR4 in the brain
      Title: TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of lipopolysaccharide receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of lipopolysaccharide receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of lipopolysaccharide receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TLR4 interactor with leucine rich repeats

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025817.4 → NP_080093.1  TLR4 interactor with leucine rich repeats precursor

      See identical proteins and their annotated locations for NP_080093.1

      Status: VALIDATED

      Source sequence(s)
      AC079130, BC059224, BY291576
      Consensus CDS
      CCDS51776.1
      UniProtKB/Swiss-Prot
      Q80TV0, Q8BKM5, Q9DBY4
      Related
      ENSMUSP00000116056.3, ENSMUST00000127748.5
      Conserved Domains (6) summary
      smart00060
      Location:587 → 659
      FN3; Fibronectin type 3 domain
      cd00116
      Location:229 → 364
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:37 → 57
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:85 → 108
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:229 → 289
      LRR_8; Leucine rich repeat
      cl15307
      Location:359 → 406
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      53792453..53797810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBY4.1 GenPept UniProtKB/Swiss-Prot:Q9DBY4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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