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    Plbd1 phospholipase B domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 66857, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Plbd1provided by MGI
    Official Full Name
    phospholipase B domain containing 1provided by MGI
    Primary source
    MGI:MGI:1914107
    See related
    Ensembl:ENSMUSG00000030214 AllianceGenome:MGI:1914107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1100001H23Rik
    Summary
    Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in 4th ventricle lateral recess; epidermis; and vibrissa. Orthologous to human PLBD1 (phospholipase B domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 22.6), testis adult (RPKM 20.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plbd1 in Genome Data Viewer
    Location:
    6 G1; 6 66.59 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136589069..136639301, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136612071..136662303, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136440301-136440484 Neighboring gene STARR-seq mESC enhancer starr_17596 Neighboring gene ribosomal protein L36A, pseudogene 3 Neighboring gene predicted gene, 44140 Neighboring gene STARR-positive B cell enhancer ABC_E691 Neighboring gene STARR-positive B cell enhancer ABC_E9106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136480481-136480679 Neighboring gene STARR-seq mESC enhancer starr_17599 Neighboring gene activating transcription factor 7 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E9282 Neighboring gene STARR-positive B cell enhancer ABC_E1715 Neighboring gene STARR-positive B cell enhancer ABC_E10415 Neighboring gene STARR-seq mESC enhancer starr_17605 Neighboring gene STARR-positive B cell enhancer ABC_E4875 Neighboring gene predicted gene, 40409 Neighboring gene protein S100-A10 pseudogene Neighboring gene guanylate cyclase 2c Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136692382-136692565

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
    2. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase B-like 1
    Names
    LAMA-like protein 1
    lamina ancestor homolog 1
    phospholipase B domain-containing protein 1
    putative phospholipase B-like 1
    NP_080082.1
    XP_006506548.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025806.2 → NP_080082.1  phospholipase B-like 1 precursor

      See identical proteins and their annotated locations for NP_080082.1

      Status: VALIDATED

      Source sequence(s)
      AC134474, AK003169
      Consensus CDS
      CCDS20652.1
      UniProtKB/Swiss-Prot
      Q3TA89, Q8VCI0, Q9D1S0
      UniProtKB/TrEMBL
      A0A0R4J0B2
      Related
      ENSMUSP00000032336.5, ENSMUST00000032336.7
      Conserved Domains (1) summary
      pfam04916
      Location:28 → 545
      Phospholip_B; Phospholipase B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      136589069..136639301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506485.5 → XP_006506548.1  phospholipase B-like 1 isoform X1

      Conserved Domains (1) summary
      pfam04916
      Location:29 → 283
      Phospholip_B; Phospholipase B
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCI0.1 GenPept UniProtKB/Swiss-Prot:Q8VCI0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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