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    Mospd1 motile sperm domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70380, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mospd1provided by MGI
    Official Full Name
    motile sperm domain containing 1provided by MGI
    Primary source
    MGI:MGI:1917630
    See related
    Ensembl:ENSMUSG00000023074 AllianceGenome:MGI:1917630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810018L05Rik
    Summary
    Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including brain; cranial ganglion; limb mesenchyme; tongue muscle; and vertebral axis musculature. Orthologous to human MOSPD1 (motile sperm domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 12.9), liver E14 (RPKM 6.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mospd1 in Genome Data Viewer
    Location:
    X A5; X 29.51 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52433471..52459567, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (53344594..53370658, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene PABIR family member 2 Neighboring gene PABIR family member 3 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene casein kinase 1, gamma 3 pseudogene Neighboring gene embryonic testis differentiation

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mospd1, a new player in mesenchymal versus epidermal cell differentiation. Thaler R, et al. J Cell Physiol, 2011 Oct. PMID 21792907
    2. A major X-linked locus affects kidney function in mice. Leduc MS, et al. Mol Genet Genomics, 2012 Dec. PMID 23011808, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • MGC103065

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    motile sperm domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290514.1 → NP_001277443.1  motile sperm domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001277443.1

      Status: VALIDATED

      Source sequence(s)
      AK139795, BF467665, BG068741, BG077592, CJ046213, DV651027
      Consensus CDS
      CCDS72381.1
      UniProtKB/Swiss-Prot
      Q497P5, Q8VEL0, Q9D8Y9
      UniProtKB/TrEMBL
      Q3UT40
      Related
      ENSMUSP00000094182.3, ENSMUST00000096447.9
      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    2. NM_001358456.1 → NP_001345385.1  motile sperm domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BG077592, BX679674
      UniProtKB/TrEMBL
      Q3UT40
      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    3. NM_027409.5 → NP_081685.1  motile sperm domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_081685.1

      Status: VALIDATED

      Source sequence(s)
      AK007533, BF467665, BG068741, BG077592, CJ046213, DV651027
      Consensus CDS
      CCDS30131.1
      UniProtKB/TrEMBL
      Q3UT40
      Related
      ENSMUSP00000023836.4, ENSMUST00000023836.4
      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    RNA

    1. NR_110964.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC085100, BG077592, CJ046213

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      52433471..52459567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541541.5 → XP_006541604.1  motile sperm domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    2. XM_006541538.4 → XP_006541601.1  motile sperm domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006541601.1

      UniProtKB/TrEMBL
      Q3UT40
      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    3. XM_011251017.3 → XP_011249319.1  motile sperm domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011249319.1

      UniProtKB/TrEMBL
      Q3UT40
      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    4. XM_030251496.2 → XP_030107356.1  motile sperm domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    5. XM_036162092.1 → XP_036017985.1  motile sperm domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    6. XM_006541540.4 → XP_006541603.1  motile sperm domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006541603.1

      UniProtKB/Swiss-Prot
      Q497P5, Q8VEL0, Q9D8Y9
      UniProtKB/TrEMBL
      Q3UT40
      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    7. XM_017318617.2 → XP_017174106.1  motile sperm domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q497P5, Q8VEL0, Q9D8Y9
      UniProtKB/TrEMBL
      Q3UT40
      Conserved Domains (1) summary
      pfam00635
      Location:16 → 113
      Motile_Sperm; MSP (Major sperm protein) domain

    RNA

    1. XR_004940365.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEL0.1 GenPept UniProtKB/Swiss-Prot:Q8VEL0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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