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    Sgk2 serum/glucocorticoid regulated kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 27219, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Sgk2provided by MGI
    Official Full Name
    serum/glucocorticoid regulated kinase 2provided by MGI
    Primary source
    MGI:MGI:1351318
    See related
    Ensembl:ENSMUSG00000017868 AllianceGenome:MGI:1351318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sgkl
    Summary
    Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in nucleoplasm. Orthologous to human SGK2 (serum/glucocorticoid regulated kinase 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in kidney adult (RPKM 26.4), liver adult (RPKM 9.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sgk2 in Genome Data Viewer
    Location:
    2 H2; 2 83.93 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162829249..162856059)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (162987327..163014139)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene L3MBTL1 histone methyl-lysine binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene intraflagellar transport 52 Neighboring gene STARR-seq mESC enhancer starr_06293 Neighboring gene STARR-seq mESC enhancer starr_06295 Neighboring gene STARR-positive B cell enhancer ABC_E6013 Neighboring gene myeloblastosis oncogene-like 2 Neighboring gene microRNA 7003

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein Kinase SGK2 Is Induced by the β(3) Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis. Park CH, et al. Front Physiol, 2021. PMID 34899399, Free PMC Article
    2. Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal. Gotoh S, et al. Cell Signal, 2017 Dec. PMID 28911860
    3. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Pao AC, et al. Am J Physiol Renal Physiol, 2010 Dec. PMID 20926631, Free PMC Article
    4. A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice. Masujin K, et al. DNA Res, 2004 Dec 31. PMID 15871460
    5. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Kobayashi T, et al. Biochem J, 1999 Nov 15. PMID 10548550, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
      Title: Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal.
    2. the nucleotide substitution in the Sgkl gene is the causative mutation for defective hair growth in the ypc mutant mouse and the signaling pathway involving SGKL plays an essential role in mammalian hair development
      Title: A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Sgk2
    NP_001278081.1
    NP_001278083.1
    NP_038759.1
    XP_006499721.1
    XP_006499723.1
    XP_011237882.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291152.1 → NP_001278081.1  serine/threonine-protein kinase Sgk2 isoform b

      See identical proteins and their annotated locations for NP_001278081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. The 5' UTR of this variant is incomplete due to lack of a complete transcript and splice pattern ambiguity in the upstream region.
      Source sequence(s)
      AK050009, AK136559, AV370098, BB350718
      UniProtKB/TrEMBL
      Q3UW73
      Conserved Domains (2) summary
      smart00220
      Location:35 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:39 → 358
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001291154.1 → NP_001278083.1  serine/threonine-protein kinase Sgk2 isoform c

      See identical proteins and their annotated locations for NP_001278083.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AI747981, AK050009, AL591584, AV370098, BB350718
      Consensus CDS
      CCDS71184.1
      UniProtKB/TrEMBL
      Q3UW73
      Related
      ENSMUSP00000112468.2, ENSMUST00000117123.2
      Conserved Domains (1) summary
      cl21453
      Location:39 → 330
      PKc_like; Protein Kinases, catalytic domain

    3. NM_013731.3 → NP_038759.1  serine/threonine-protein kinase Sgk2 isoform a

      See identical proteins and their annotated locations for NP_038759.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI747981, AK050009, AK136559, AV370098, BB350718
      Consensus CDS
      CCDS17004.1
      UniProtKB/Swiss-Prot
      B7ZC31, Q8R0P6, Q9QZS5
      UniProtKB/TrEMBL
      Q3UW73
      Related
      ENSMUSP00000018012.8, ENSMUST00000018012.14
      Conserved Domains (1) summary
      cl21453
      Location:39 → 359
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      162829249..162856059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499660.5 → XP_006499723.1  serine/threonine-protein kinase Sgk2 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:39 → 283
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011239580.3 → XP_011237882.1  serine/threonine-protein kinase Sgk2 isoform X2

      See identical proteins and their annotated locations for XP_011237882.1

      UniProtKB/TrEMBL
      Q3UW73
      Conserved Domains (1) summary
      cl21453
      Location:39 → 330
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006499658.5 → XP_006499721.1  serine/threonine-protein kinase Sgk2 isoform X1

      See identical proteins and their annotated locations for XP_006499721.1

      UniProtKB/Swiss-Prot
      B7ZC31, Q8R0P6, Q9QZS5
      UniProtKB/TrEMBL
      Q3UW73
      Conserved Domains (1) summary
      cl21453
      Location:39 → 359
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZS5.1 GenPept UniProtKB/Swiss-Prot:Q9QZS5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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