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    Saf-B Scaffold attachment factor B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42958, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Saf-Bprovided by FlyBase
    Official Full Name
    Scaffold attachment factor Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039229
    Locus tag
    Dmel_CG6995
    See related
    AllianceGenome:FB:FBgn0039229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6995; CG6995; Dmel\CG6995; LD22822; saf-b; SAF-B; SAFB
    Summary
    Predicted to enable mRNA binding activity and sequence-specific DNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear matrix and nucleoplasm. Is expressed in several structures, including anterior-posterior subdivision of organism; germline cell; larval brain; larval central nervous system; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including SAFB (scaffold attachment factor B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Saf-B in Genome Data Viewer
    Location:
    96A23-96A23; 3-85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24817464..24822350)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20643186..20648072)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46096 Neighboring gene uncharacterized protein Neighboring gene nimA-like kinase Neighboring gene long non-coding RNA:CR43166

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila SAF-B links the nuclear matrix, chromosomes, and transcriptional activity. Alfonso-Parra C, et al. PLoS One, 2010 Apr 20. PMID 20422039, Free PMC Article
    2. Dynamics of hnRNPs and omega speckles in normal and heat shocked live cell nuclei of Drosophila melanogaster. Singh AK, et al. Chromosoma, 2015 Sep. PMID 25663367
    3. BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Fujiyama-Nakamura S, et al. Genes Cells, 2009 Aug. PMID 19624754
    4. Autonomous transposons tune their sequences to ensure somatic suppression. Ilık İA, et al. Nature, 2024 Feb. PMID 38355802, Free PMC Article
    5. From Heterochromatin to Long Noncoding RNAs in Drosophila: Expanding the Arena of Gene Function and Regulation. Lakhotia SC. Adv Exp Med Biol, 2017. PMID 28815537

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scaffold attachment factor B
    Names
    CG6995-PB
    CG6995-PD
    CG6995-PE
    CG6995-PF
    Saf-B-PB
    Saf-B-PD
    Saf-B-PE
    Saf-B-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24817464..24822350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316518.1 → NP_001303447.1  scaffold attachment factor B, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GV03
      Conserved Domains (1) summary
      pfam02037
      Location:11 → 42
      SAP; SAP domain

    2. NM_001316517.1 → NP_001303446.1  scaffold attachment factor B, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GV03
      Conserved Domains (1) summary
      pfam02037
      Location:11 → 42
      SAP; SAP domain

    3. NM_170169.3 → NP_733041.2  scaffold attachment factor B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733041.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGV1, Q8IMV6
      Related
      FBpp0084078
      Conserved Domains (4) summary
      COG0724
      Location:205 → 394
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12417
      Location:313 → 386
      RRM_SAFB_like; RNA recognition motif in the scaffold attachment factor (SAFB) family
      pfam02037
      Location:11 → 42
      SAP; SAP domain
      pfam16495
      Location:588 → 618
      SWIRM-assoc_1; SWIRM-associated region 1

    4. NM_001276002.1 → NP_001262931.1  scaffold attachment factor B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGV9
      Conserved Domains (1) summary
      pfam02037
      Location:11 → 42
      SAP; SAP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGV9 A0A0B4KGV9
    A0A126GV03 A0A126GV03
    Q7K1P7 Q7K1P7
    Q8IGV1 Q8IGV1
    Q8IMV6 Q8IMV6

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