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    Zfrp8 Zinc finger protein RP-8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45021, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfrp8provided by FlyBase
    Official Full Name
    Zinc finger protein RP-8provided by FlyBase
    Primary source
    FLYBASE:FBgn0021875
    Locus tag
    Dmel_CG3260
    See related
    AllianceGenome:FB:FBgn0021875
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    137/5; CG3260; Dmel\CG3260; l(2)k13705; PDCD2; zfrp8
    Summary
    Enables ribosomal small subunit binding activity. Involved in several processes, including embryonic hemopoiesis; regulation of cytoplasmic translation; and somatic stem cell division. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; germarium; and mesoderm. Orthologous to human PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See Zfrp8 in Genome Data Viewer
    Location:
    60B11-60B12; 2-106 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24133989..24135405)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20021512..20022928)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tamo Neighboring gene long non-coding RNA:CR44826 Neighboring gene N(alpha)-acetyltransferase 35 Neighboring gene speck Neighboring gene DnaJ-like-60 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic stem cells in Drosophila. Minakhina S, et al. Development, 2010 Jan. PMID 20023157, Free PMC Article
    2. Zfrp8/PDCD2 Interacts with RpS2 Connecting Ribosome Maturation and Gene-Specific Translation. Minakhina S, et al. PLoS One, 2016. PMID 26807849, Free PMC Article
    3. Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery. Minakhina S, et al. Development, 2014 Jan. PMID 24381196, Free PMC Article
    4. Drosophila melanogaster as a Model to Study the Multiple Phenotypes, Related to Genome Stability of the Fragile-X Syndrome. Specchia V, et al. Front Genet, 2019. PMID 30815010, Free PMC Article
    5. Tamo selectively modulates nuclear import in Drosophila. Minakhina S, et al. Genes Cells, 2003 Apr. PMID 12653959

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results suggest that Zfrp8/PDCD2 functions at late stages of ribosome assembly and may regulate the binding of specific mRNA-RNPs to the small ribosomal subunit ultimately controlling their cytoplasmic localization and translation.
      Title: Zfrp8/PDCD2 Interacts with RpS2 Connecting Ribosome Maturation and Gene-Specific Translation.
    2. demonstrate that Zfrp8 genetically interacts with Fmr1 and tral in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways
      Title: Zfrp8 forms a complex with fragile-X mental retardation protein and regulates its localization and function.
    3. The piRNA pathway is essential in early oogenesis, and we find that nuclear localization of Zfrp8 in germline stem cells and their offspring is regulated by some piRNA pathway genes.
      Title: Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery.
    4. Data find that the conserved factor Zfrp8/PDCD2 is essential for the maintenance of the hematopoietic stem cells, but dispensable for their daughter cells, the pluripotent precursors.
      Title: Hematopoietic stem cells in Drosophila.
    5. Zfrp8 is involved in the regulation of cell proliferation from embryonic stages onward, through the function of the centrosome, and regulates the level and localization of cell-cycle components
      Title: Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribosomal small subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in somatic stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein RP-8
    Names
    CG3260-PA
    CG3260-PB
    Zfrp8-PA
    Zfrp8-PB
    programmed cell death 2
    zinc finger RP8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24133989..24135405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138046.2 → NP_611890.1  zinc finger protein RP-8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZ50, Q9W1A3
      Related
      FBpp0072162
      Conserved Domains (2) summary
      pfam01753
      Location:128 → 164
      zf-MYND; MYND finger
      pfam04194
      Location:238 → 340
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

    2. NM_001299899.1 → NP_001286828.1  zinc finger protein RP-8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286828.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZ50, Q9W1A3
      Conserved Domains (2) summary
      pfam01753
      Location:128 → 164
      zf-MYND; MYND finger
      pfam04194
      Location:238 → 340
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZ50 Q8MZ50
    Q9W1A3 Q9W1A3

    Gene LinkOut

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