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    CG9485 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37435, updated on 22-Aug-2024

    Summary

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    Official Symbol
    CG9485provided by FlyBase
    Primary source
    FLYBASE:FBgn0034618
    Locus tag
    Dmel_CG9485
    See related
    AllianceGenome:FB:FBgn0034618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH22856; Dmel\CG9485
    Summary
    Predicted to enable 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Predicted to be involved in glycogen catabolic process. Is expressed in several structures, including central brain primordium; embryonic brain; embryonic epidermis; embryonic/larval somatic muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG9485 in Genome Data Viewer
    Location:
    57D11-57D11; 2-94 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21312399..21319569)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17199904..17207074)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat-rich membrane spanning Neighboring gene antisense RNA:CR45149 Neighboring gene Panoramix Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene domino

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila. Yamada T, et al. Development, 2018 Mar 14. PMID 29467247
    2. TOR signalling is required for host lipid metabolic remodelling and survival following enteric infection in Drosophila. Deshpande R, et al. Dis Model Mech, 2022 May 1. PMID 35363274, Free PMC Article
    3. The computational analysis of scientific literature to define and recognize gene expression clusters. Raychaudhuri S, et al. Nucleic Acids Res, 2003 Aug 1. PMID 12888516, Free PMC Article
    4. Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Dionne MS, et al. Curr Biol, 2006 Oct 24. PMID 17055976
    5. Nuclear translocation ability of Lipin differentially affects gene expression and survival in fed and fasting Drosophila. Hood SE, et al. J Lipid Res, 2020 Dec. PMID 32989002, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4-alpha-glucanotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-alpha-glucanotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-alpha-glucanotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amylo-alpha-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amylo-alpha-1,6-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amylo-alpha-1,6-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9485-PA
    CG9485-PB
    CG9485-PC
    CG9485-PD
    CG9485-PE
    CG9485-PF
    NP_001163234.1
    NP_001163235.1
    NP_001261123.1
    NP_611577.2
    NP_726061.1
    NP_726062.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21312399..21319569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274194.2 → NP_001261123.1  uncharacterized protein Dmel_CG9485, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAD6, Q7KVP4
      Conserved Domains (6) summary
      cd11327
      Location:125 → 617
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:25 → 1534
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1060 → 1529
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:34 → 137
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:723 → 993
      hGDE_central; central domain of human glycogen debranching enzyme
      cl10013
      Location:989 → 1063
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    2. NM_001169763.2 → NP_001163234.1  uncharacterized protein Dmel_CG9485, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163234.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAD6, E1JGQ5
      Conserved Domains (6) summary
      cd11327
      Location:146 → 638
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:25 → 1555
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1081 → 1550
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:34 → 158
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:744 → 1014
      hGDE_central; central domain of human glycogen debranching enzyme
      cl10013
      Location:1010 → 1084
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    3. NM_166443.2 → NP_726061.1  uncharacterized protein Dmel_CG9485, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726061.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAD6, Q7KVP4
      Related
      FBpp0071525
      Conserved Domains (6) summary
      cd11327
      Location:125 → 617
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:25 → 1534
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1060 → 1529
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:34 → 137
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:723 → 993
      hGDE_central; central domain of human glycogen debranching enzyme
      cl10013
      Location:989 → 1063
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    4. NM_001169764.2 → NP_001163235.1  uncharacterized protein Dmel_CG9485, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163235.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAD6, Q7KVP4
      Conserved Domains (6) summary
      cd11327
      Location:125 → 617
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:25 → 1534
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1060 → 1529
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:34 → 137
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:723 → 993
      hGDE_central; central domain of human glycogen debranching enzyme
      cl10013
      Location:989 → 1063
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    5. NM_166444.2 → NP_726062.2  uncharacterized protein Dmel_CG9485, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726062.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAB1, Q9W2H8
      Related
      FBpp0071526
      Conserved Domains (7) summary
      cd11327
      Location:212 → 704
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:112 → 1621
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1147 → 1616
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam06870
      Location:30 → 76
      RNA_pol_I_A49; A49-like RNA polymerase I associated factor
      pfam14699
      Location:121 → 224
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:810 → 1080
      hGDE_central; central domain of human glycogen debranching enzyme
      cl10013
      Location:1076 → 1150
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    6. NM_137733.3 → NP_611577.2  uncharacterized protein Dmel_CG9485, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611577.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAD6, Q86BS7
      Related
      FBpp0071527
      Conserved Domains (6) summary
      cd11327
      Location:129 → 621
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:29 → 1538
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1064 → 1533
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:38 → 141
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:727 → 997
      hGDE_central; central domain of human glycogen debranching enzyme
      cl10013
      Location:993 → 1067
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JGQ5 E1JGQ5
    Q7KVP4 Q7KVP4
    Q86BS7 Q86BS7
    Q960T9 Q960T9
    Q9W2H8 Q9W2H8

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