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    Gnpnat Glucosamine-phosphate N-acetyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43504, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gnpnatprovided by FlyBase
    Official Full Name
    Glucosamine-phosphate N-acetyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039690
    Locus tag
    Dmel_CG1969
    See related
    AllianceGenome:FB:FBgn0039690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1969; Dmel\CG1969; GNPNAT
    Summary
    Predicted to enable glucosamine 6-phosphate N-acetyltransferase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; dorsal epidermis primordium; embryonic proventriculus; embryonic proventriculus intermediate layer; and epithelium. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Gnpnat in Genome Data Viewer
    Location:
    99B9-99B9; 3-99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29738275..29741952)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25563997..25567674)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Kuzbanian-like Neighboring gene uncharacterized protein Neighboring gene Complex I intermediate-associated protein, 30 kDa Neighboring gene WD repeat domain 24 Neighboring gene antisense RNA:CR46109 Neighboring gene Integrator 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mosquito glucosamine-6-phosphate N-acetyltransferase: cDNA, gene structure and enzyme kinetics. Kato N, et al. Insect Biochem Mol Biol, 2005 Jun. PMID 15857769
    2. Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange. van den Berg L, et al. Cell Rep, 2023 Jul 25. PMID 37405919
    3. Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms. Saha N, et al. BMC Genomics, 2016 Feb 13. PMID 26872827, Free PMC Article
    4. Isolation of microRNA targets by miRNP immunopurification. Easow G, et al. RNA, 2007 Aug. PMID 17592038, Free PMC Article
    5. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. Xie J, et al. PLoS Genet, 2021 May. PMID 33983927, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucosamine 6-phosphate N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosamine 6-phosphate N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Glucosamine-phosphate N-acetyltransferase
    Names
    CG1969-PA
    CG1969-PB
    CG1969-PD
    CG1969-PE
    CG1969-PF
    CG1969-PG
    CG1969-PH
    Gnpnat-PA
    Gnpnat-PB
    Gnpnat-PD
    Gnpnat-PE
    Gnpnat-PF
    Gnpnat-PG
    Gnpnat-PH
    glucosamine-phosphate N-acetyltransferase
    NP_001247360.1
    NP_001247361.1
    NP_001263079.1
    NP_001263080.1
    NP_001263081.1
    NP_651719.1
    NP_733301.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29738275..29741952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276150.1 → NP_001263079.1  Glucosamine-phosphate N-acetyltransferase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP97, Q8IMK5
      Conserved Domains (1) summary
      cl17182
      Location:39 → 170
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    2. NM_170422.3 → NP_733301.1  Glucosamine-phosphate N-acetyltransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP97, Q8IMK5
      Related
      FBpp0084840
      Conserved Domains (1) summary
      cl17182
      Location:39 → 170
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    3. NM_001276152.1 → NP_001263081.1  Glucosamine-phosphate N-acetyltransferase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI57, C6TP97
      Conserved Domains (1) summary
      cl17182
      Location:39 → 170
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    4. NM_001260431.2 → NP_001247360.1  Glucosamine-phosphate N-acetyltransferase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP97, C6TP98
      Conserved Domains (1) summary
      cl17182
      Location:39 → 170
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    5. NM_143462.4 → NP_651719.1  Glucosamine-phosphate N-acetyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VAI0
      UniProtKB/TrEMBL
      C6TP97
      Related
      FBpp0084841
      Conserved Domains (1) summary
      cl17182
      Location:43 → 174
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    6. NM_001276151.1 → NP_001263080.1  Glucosamine-phosphate N-acetyltransferase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263080.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP97, Q8IMK5
      Conserved Domains (1) summary
      cl17182
      Location:39 → 170
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    7. NM_001260432.2 → NP_001247361.1  Glucosamine-phosphate N-acetyltransferase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7R2, C6TP97
      Conserved Domains (1) summary
      cl17182
      Location:43 → 174
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7R2 A0A0B4K7R2
    A0A0B4KI57 A0A0B4KI57
    C6TP98 C6TP98
    Q8IMK5 Q8IMK5
    Q9VAI0.1 Q9VAI0

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