ak3 adenylate kinase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ak3provided by ZNC
Official Full Name: adenylate kinase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2142
See related: Ensembl:ENSDARG00000058226 AllianceGenome:ZFIN:ZDB-GENE-040426-2142
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ak3l1; sb:cb845; zgc:64135; id:ibd3034; wu:fa02c11; wu:fc20h08
Summary: Predicted to enable adenylate kinase activity and nucleoside triphosphate adenylate kinase activity. Acts upstream of or within myeloid cell development. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in blood; brain; notochord; tail bud; and yolk syncytial layer. Orthologous to human AK3 (adenylate kinase 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (11000834..11011984, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (11042596..11053746, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA495371 (e-PCR)
- UniSTS:206950

fe15h10.y1 (e-PCR)
- UniSTS:196231

fc20h08.x1 (e-PCR)
- UniSTS:187795

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleobase-containing compound kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside triphosphate adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, phosphate group as acceptor	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GTP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ITP metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTP:AMP phosphotransferase AK3, mitochondrial

Names: adenylate kinase 3-like 1

NP_998295.2

EC 2.7.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213130.2 → NP_998295.2 GTP:AMP phosphotransferase AK3, mitochondrial

Status: VALIDATED

Source sequence(s)

CT027818, EH501641

UniProtKB/TrEMBL

A0A8M1PGD5, F1R4S7

Related

ENSDARP00000116187.1, ENSDART00000132995.2

Conserved Domains (2) summary

PRK00279
Location:8 → 198

adk; adenylate kinase; Reviewed

cd01428
Location:8 → 200

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...