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    sh3gl1a SH3-domain GRB2-like 1a [ Danio rerio (zebrafish) ]

    Gene ID: 100005753, updated on 17-Sep-2024

    Summary

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    Official Symbol
    sh3gl1aprovided by ZNC
    Official Full Name
    SH3-domain GRB2-like 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4524
    See related
    Ensembl:ENSDARG00000067958 AllianceGenome:ZFIN:ZDB-GENE-030131-4524
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sh3gl1b; zgc:56637; wu:fd12b05; wu:fy33c10
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in synaptic vesicle uncoating. Predicted to be located in early endosome membrane. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in several structures, including EVL; digestive system; epidermis; hatching gland; and periderm. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See sh3gl1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (49457638..49511458)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (49723401..49777228)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba Neighboring gene RAR-related orphan receptor C b Neighboring gene si:ch211-209f23.3 Neighboring gene signal transducing adaptor family member 2a Neighboring gene semaphorin 4e

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Essential role of SH3-domain GRB2-like 3 for vascular lumen maintenance in zebrafish. Zhao Y, et al. Arterioscler Thromb Vasc Biol, 2013 Jun. PMID 23539215
    2. eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish. Le HY, et al. J Biol Chem, 2008 Jun 20. PMID 18413315
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56637

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in synaptic vesicle uncoating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH3-domain GRB2-like 1a
    Names
    SH3-domain GRB2-like 1b
    eenb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105606.1 → NP_001099076.1  SH3-domain GRB2-like 1a isoform 1

      See identical proteins and their annotated locations for NP_001099076.1

      Status: PROVISIONAL

      Source sequence(s)
      BC153638
      UniProtKB/TrEMBL
      A8E5L6, F6NXU5, Q1MT71
      Related
      ENSDARP00000110333.2, ENSDART00000129967.3
      Conserved Domains (2) summary
      cd07592
      Location:25 → 247
      BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
      cd11803
      Location:307 → 361
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

    2. NM_200301.1 → NP_956595.1  SH3-domain GRB2-like 1a isoform 2

      See identical proteins and their annotated locations for NP_956595.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049513
      UniProtKB/TrEMBL
      Q7ZWA0
      Conserved Domains (2) summary
      cd07592
      Location:25 → 247
      BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
      cd11803
      Location:307 → 361
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      49457638..49511458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222410.1 → XP_068078511.1  SH3-domain GRB2-like 1a isoform X1

      Related
      ENSDARP00000151484.1, ENSDART00000185470.1
    Nucleotide Protein
    Heading Accession and Version

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