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    lrrc4.1 leucine rich repeat containing 4.1 [ Danio rerio (zebrafish) ]

    Gene ID: 565021, updated on 12-Sep-2024

    Summary

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    Official Symbol
    lrrc4.1provided by ZNC
    Official Full Name
    leucine rich repeat containing 4.1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-129
    See related
    Ensembl:ENSDARG00000069402 AllianceGenome:ZFIN:ZDB-GENE-041210-129
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lrrc4a; si:ch211-235l7.2
    Summary
    Predicted to be involved in modulation of chemical synaptic transmission and synapse organization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in glutamatergic synapse and plasma membrane. Predicted to be integral component of postsynaptic density membrane. Is expressed in basal plate midbrain region; nervous system; and neural plate. Orthologous to human LRRC4 (leucine rich repeat containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See lrrc4.1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (19534820..19539086)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (19545373..19549637)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491540 Neighboring gene uncharacterized LOC137491541 Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene uncharacterized LOC101883798 Neighboring gene paired box 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A cell surface interaction network of neural leucine-rich repeat receptors. Söllner C, et al. Genome Biol, 2009. PMID 19765300, Free PMC Article
    2. The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Panza P, et al. Neural Dev, 2015 Oct 22. PMID 26492970, Free PMC Article
    3. Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Martin S, et al. Mol Cell Proteomics, 2010 Dec. PMID 20802085, Free PMC Article
    4. The impact of gene expression regulation on evolution of extracellular signaling pathways. Charoensawan V, et al. Mol Cell Proteomics, 2010 Dec. PMID 20935258, Free PMC Article
    5. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in excitatory synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic density protein 95 clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 4
    Names
    leucine rich repeat containing 4a
    lrrc4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      19534820..19539086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164787.5 → XP_005164844.1  leucine-rich repeat-containing protein 4

      UniProtKB/TrEMBL
      A0A8M2BBZ6, E9QDQ3, I7HJH4
      Related
      ENSDARP00000122550.1, ENSDART00000140028.2
      Conserved Domains (7) summary
      smart00013
      Location:43 → 77
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:361 → 443
      IG_like; Immunoglobulin like
      cd00116
      Location:93 → 323
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:54 → 73
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05217
      Location:616 → 799
      STOP; STOP protein
      pfam13855
      Location:76 → 133
      LRR_8; Leucine rich repeat
      cl11960
      Location:372 → 443
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001030194.1: Suppressed sequence

      Description
      NM_001030194.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version

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