Myocd myocardin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myocdprovided by MGI
Official Full Name: myocardinprovided by MGI
Primary source: MGI:MGI:2137495
See related: Ensembl:ENSMUSG00000020542 AllianceGenome:MGI:2137495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Srfcp; BSAC2A
Summary: Enables several functions, including R-SMAD binding activity; enzyme binding activity; and transcription coactivator activity. Involved in several processes, including circulatory system development; positive regulation of macromolecule biosynthetic process; and regulation of signal transduction. Acts upstream of or within several processes, including circulatory system development; negative regulation of cardiac muscle cell apoptotic process; and regulation of DNA-templated transcription. Located in chromatin and nucleus. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; genitourinary system; gut; and respiratory system. Used to study congenital megabladder; dilated cardiomyopathy; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in congenital megabladder. Orthologous to human MYOCD (myocardin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 12.8), heart adult (RPKM 7.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 40.42 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (65064434..65160821, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (65173608..65269989, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H[+]-ATPase V0d1 subunit.
Title: Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H(+)-ATPase V0d1 subunit.
Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes.
Title: Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes.
Long noncoding RNA TUG1 regulates smooth muscle cell differentiation via KLF4-myocardin axis.
Title: Long noncoding RNA TUG1 regulates smooth muscle cell differentiation via KLF4-myocardin axis.
SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin.
Title: SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin.
Myocardin-related transcription factor contributes to renal fibrosis through the regulation of extracellular microenvironment surrounding fibroblasts.
Title: Myocardin-related transcription factor contributes to renal fibrosis through the regulation of extracellular microenvironment surrounding fibroblasts.
Actin-related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2.
Title: Actin-related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2.
Myocd regulates airway smooth muscle cell remodeling in response to chronic asthmatic injury.
Title: Myocd regulates airway smooth muscle cell remodeling in response to chronic asthmatic injury.
MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin.
Title: MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin.
CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin.
Title: CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin.
Myocardin suppression increases lipid retention and atherosclerosis via downregulation of ABCA1 in vascular smooth muscle cells.
Title: Myocardin suppression increases lipid retention and atherosclerosis via downregulation of ABCA1 in vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myocd (e-PCR), detects polymorphism
- UniSTS:463419

Myocd (e-PCR), detects polymorphism
- UniSTS:532558

Myocd (e-PCR), detects polymorphism
- UniSTS:532559

D11Mit177 (e-PCR), detects polymorphism
- UniSTS:126372

PMC309615P1 (e-PCR)
- UniSTS:272593

PMC309615P2 (e-PCR)
- UniSTS:272594

PMC150745P1 (e-PCR)
- UniSTS:271101

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac vascular smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular component maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ductus arteriosus closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatic stellate cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of cell adhesion molecule production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of skeletal muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell growth by extracellular stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phenotypic switching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within urinary bladder development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urinary bladder development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular associated smooth muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SRF-myogenin-E12 complex	IC Inferred by Curator more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myocardin

Names: SRF co-factor protein (cardiac and smooth muscle); SRF cofactor protein; basic SAP coiled-coil transcription activator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145136.5 → NP_660118.3 myocardin isoform A

See identical proteins and their annotated locations for NP_660118.3

Status: VALIDATED

Source sequence(s)

AL669846

Consensus CDS

CCDS48819.1

UniProtKB/TrEMBL

B9EJ16

Related

ENSMUSP00000104335.3, ENSMUST00000108695.9

Conserved Domains (2) summary

smart00707
Location:106 → 131

RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

pfam02037
Location:380 → 413

SAP; SAP domain
NM_146386.4 → NP_666498.2 myocardin isoform B

See identical proteins and their annotated locations for NP_666498.2

Status: VALIDATED

Source sequence(s)

AL669846

Consensus CDS

CCDS24843.1

UniProtKB/Swiss-Prot

Q5SS65, Q6W8X1, Q8C3W6, Q8VIL4, Q8VIM5

UniProtKB/TrEMBL

B9EJ16

Related

ENSMUSP00000099695.4, ENSMUST00000102635.10

Conserved Domains (2) summary

smart00707
Location:106 → 131

RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

pfam02037
Location:380 → 413

SAP; SAP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

65064434..65160821 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248893.3 → XP_011247195.1 myocardin isoform X1

UniProtKB/TrEMBL

B9EJ16

Conserved Domains (2) summary

smart00707
Location:119 → 144

RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

pfam02037
Location:396 → 426

SAP; SAP domain
XM_011248895.1 → XP_011247197.1 myocardin isoform X2

UniProtKB/TrEMBL

B9EJ16

Related

ENSMUSP00000098603.3, ENSMUST00000101042.9

Conserved Domains (2) summary

smart00707
Location:27 → 52

RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

pfam02037
Location:304 → 334

SAP; SAP domain