Naxe NAD(P)HX epimerase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naxeprovided by MGI
Official Full Name: NAD(P)HX epimeraseprovided by MGI
Primary source: MGI:MGI:2180167
See related: Ensembl:ENSMUSG00000028070 AllianceGenome:MGI:2180167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AIBP; AI-BP; ESTM37; Apoa1bp; Apoa1ip
Summary: Enables identical protein binding activity. Predicted to be involved in several processes, including membrane raft distribution; negative regulation of angiogenesis; and regulation of cholesterol efflux. Located in several cellular components, including cell body; extracellular space; and mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and skeletal muscle tissue. Orthologous to human NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 55.9), adrenal adult (RPKM 49.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.78 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87963827..87965851, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88056520..88058542, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease.
Title: AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease.
AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons.
Title: AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons.
AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration.
Title: AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration.
Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization.
Title: Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization.
These results indicate that the combination of APOA-I and AIBP has an obvious anticancer effect on colorectal cancer by promoting cholesterol efflux.
Title: AIBP and APOA-I synergistically inhibit intestinal tumor growth and metastasis by promoting cholesterol efflux.
These findings demonstrate a mechanism by which AIBP regulates neuroinflammation.
Title: Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States.
data demonstrate that AIBP confers protection against diet-induced metabolic abnormalities and atherosclerosis
Title: AIBP protects against metabolic abnormalities and atherosclerosis.
Loss of Apoa1bp increased vascular density and facilitated the recovery of blood vessel perfusion function in a hindlimb ischemia model.
Title: AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.
The Aibp gene encodes two different proteins, both targeted to the mitochondria (mAIBP) and cytosol (cAIBP) confirming the presence of dehydratase and epimerase in the cytosol and mitochondria.
Title: Occurrence and subcellular distribution of the NADPHX repair system in mammals.
AI-BP plays an important role in capacitation possibly providing a link between protein phosphorylation and cholesterol efflux.
Title: Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA087124 (e-PCR), detects polymorphism
- UniSTS:143023

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD(P)HX epimerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD(P)HX epimerase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in membrane raft distribution	ISO Inferred from Sequence Orthology more info
involved_in membrane raft distribution	ISS Inferred from Sequence or Structural Similarity more info
involved_in metabolite repair	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in nicotinamide nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nicotinamide nucleotide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NAD(P)H-hydrate epimerase

Names: apoA-I binding protein; apolipoprotein A-I binding protein; apolipoprotein A-I interacting protein

NP_001396696.1

EC 5.1.99.6

NP_001396697.1

EC 5.1.99.6

NP_001396699.1

EC 5.1.99.6

NP_001396700.1

EC 5.1.99.6

NP_001396702.1

EC 5.1.99.6

NP_001396703.1

EC 5.1.99.6

NP_001396704.1

EC 5.1.99.6

NP_001396705.1

EC 5.1.99.6

NP_001396706.1

EC 5.1.99.6

NP_001396707.1

EC 5.1.99.6

NP_001396708.1

EC 5.1.99.6

NP_001396709.1

EC 5.1.99.6

NP_659146.1

EC 5.1.99.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409767.1 → NP_001396696.1 NAD(P)H-hydrate epimerase isoform 1

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409768.1 → NP_001396697.1 NAD(P)H-hydrate epimerase isoform 3

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409770.1 → NP_001396699.1 NAD(P)H-hydrate epimerase isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409771.1 → NP_001396700.1 NAD(P)H-hydrate epimerase isoform 5

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409773.1 → NP_001396702.1 NAD(P)H-hydrate epimerase isoform 6

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409774.1 → NP_001396703.1 NAD(P)H-hydrate epimerase isoform 7

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409775.1 → NP_001396704.1 NAD(P)H-hydrate epimerase isoform 8

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409776.1 → NP_001396705.1 NAD(P)H-hydrate epimerase isoform 9 precursor

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409777.1 → NP_001396706.1 NAD(P)H-hydrate epimerase isoform 10 precursor

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409778.1 → NP_001396707.1 NAD(P)H-hydrate epimerase isoform 11 precursor

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409779.1 → NP_001396708.1 NAD(P)H-hydrate epimerase isoform 12

Status: VALIDATED

Source sequence(s)

AC137525
NM_001409780.1 → NP_001396709.1 NAD(P)H-hydrate epimerase isoform 13

Status: VALIDATED

Source sequence(s)

AC137525
NM_144897.4 → NP_659146.1 NAD(P)H-hydrate epimerase isoform 2 precursor

See identical proteins and their annotated locations for NP_659146.1

Status: VALIDATED

Source sequence(s)

AC137525

Consensus CDS

CCDS17464.1

UniProtKB/Swiss-Prot

Q8K4Z3

Related

ENSMUSP00000029708.7, ENSMUST00000029708.8

Conserved Domains (1) summary

cl00318
Location:46 → 281

YjeF_N; YjeF-related protein N-terminus