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    Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 66860, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tanc1provided by MGI
    Official Full Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1provided by MGI
    Primary source
    MGI:MGI:1914110
    See related
    Ensembl:ENSMUSG00000035168 AllianceGenome:MGI:1914110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tanc; mKIAA1728; 1200003E16Rik
    Summary
    Acts upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Located in axon terminus; dendrite; and neuronal cell body. Is expressed in mandible; maxilla; metanephros; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 4.4), lung adult (RPKM 3.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tanc1 in Genome Data Viewer
    Location:
    2 C1.1; 2 33.93 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (59442167..59676557)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (59611821..59846213)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm717 Neighboring gene mitochondrial ribosomal protein S18B pseudogene Neighboring gene STARR-seq mESC enhancer starr_04580 Neighboring gene STARR-seq mESC enhancer starr_04583 Neighboring gene predicted gene, 53240 Neighboring gene STARR-seq mESC enhancer starr_04592 Neighboring gene VISTA enhancer mm282 Neighboring gene WD repeat, SAM and U-box domain containing 1 Neighboring gene predicted gene, 52554 Neighboring gene STARR-seq mESC enhancer starr_04594 Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene STARR-seq mESC enhancer starr_04597 Neighboring gene STARR-seq mESC enhancer starr_04598 Neighboring gene STARR-seq mESC enhancer starr_04600 Neighboring gene predicted gene 13572

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation. Yang Q, et al. Biochim Biophys Acta Mol Cell Res, 2024 Feb. PMID 38092135
    2. Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. Avirneni-Vadlamudi U, et al. J Clin Invest, 2012 Jan. PMID 22182840, Free PMC Article
    3. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. Han S, et al. J Neurosci, 2010 Nov 10. PMID 21068316, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    5. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
      Title: Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
    2. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory
      Title: Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein TANC1
    Names
    TPR domain, ankyrin-repeat and coiled-coil-containing protein
    tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290659.1 → NP_001277588.1  protein TANC1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. The 5' UTR of this variant is incomplete due to a lack of full-length transcript support and splice pattern ambiguity in the upstream region.
      Source sequence(s)
      AK031162, AK079966, BC079914, BY753173, CX769146
      Consensus CDS
      CCDS71057.1
      UniProtKB/TrEMBL
      B9EJ77, E9QAF9
      Conserved Domains (5) summary
      PHA03095
      Location:896 → 1208
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1275 → 1406
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1282 → 1307
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1135 → 1165
      ANK; ANK repeat [structural motif]
      cl39094
      Location:1082 → 1306
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_198294.3 → NP_938036.2  protein TANC1 isoform a

      See identical proteins and their annotated locations for NP_938036.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). The 5'-most non-coding exon of this variant is inferred based on partial transcript alignments.
      Source sequence(s)
      AK031162, AK079966, BC079914, BY753173, CX769146
      Consensus CDS
      CCDS16054.1
      UniProtKB/Swiss-Prot
      A2AUL4, A2AUL6, Q0VGY8, Q80VD2, Q8C0Q6
      UniProtKB/TrEMBL
      B9EJ77
      Related
      ENSMUSP00000036003.5, ENSMUST00000037526.11
      Conserved Domains (5) summary
      PHA03095
      Location:903 → 1215
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1282 → 1413
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1289 → 1314
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1142 → 1172
      ANK; ANK repeat [structural motif]
      cl39094
      Location:1089 → 1313
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      59442167..59676557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319203.3 → XP_017174692.1  protein TANC1 isoform X1

      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (6) summary
      PHA03095
      Location:921 → 1233
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1300 → 1431
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1307 → 1332
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1160 → 1190
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1510 → 1802
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:1107 → 1331
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_030251967.1 → XP_030107827.1  protein TANC1 isoform X4

      UniProtKB/TrEMBL
      B9EJ77, E9QAF9
      Conserved Domains (5) summary
      PHA03095
      Location:896 → 1208
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1275 → 1406
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1282 → 1307
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1135 → 1165
      ANK; ANK repeat [structural motif]
      cl39094
      Location:1082 → 1306
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_017319205.3 → XP_017174694.1  protein TANC1 isoform X4

      UniProtKB/TrEMBL
      B9EJ77, E9QAF9
      Related
      ENSMUSP00000108187.2, ENSMUST00000112568.8
      Conserved Domains (5) summary
      PHA03095
      Location:896 → 1208
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1275 → 1406
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1282 → 1307
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1135 → 1165
      ANK; ANK repeat [structural motif]
      cl39094
      Location:1082 → 1306
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_036162490.1 → XP_036018383.1  protein TANC1 isoform X3

      UniProtKB/Swiss-Prot
      A2AUL4, A2AUL6, Q0VGY8, Q80VD2, Q8C0Q6
      UniProtKB/TrEMBL
      B9EJ77
      Related
      ENSMUSP00000123345.3, ENSMUST00000139863.3
      Conserved Domains (5) summary
      PHA03095
      Location:903 → 1215
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1282 → 1413
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1289 → 1314
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1142 → 1172
      ANK; ANK repeat [structural motif]
      cl39094
      Location:1089 → 1313
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_006500034.5 → XP_006500097.1  protein TANC1 isoform X1

      See identical proteins and their annotated locations for XP_006500097.1

      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (6) summary
      PHA03095
      Location:921 → 1233
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1300 → 1431
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1307 → 1332
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1160 → 1190
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1510 → 1802
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:1107 → 1331
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_017319200.3 → XP_017174689.1  protein TANC1 isoform X1

      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (6) summary
      PHA03095
      Location:921 → 1233
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1300 → 1431
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1307 → 1332
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1160 → 1190
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1510 → 1802
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:1107 → 1331
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_030251966.2 → XP_030107826.1  protein TANC1 isoform X1

      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (6) summary
      PHA03095
      Location:921 → 1233
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1300 → 1431
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1307 → 1332
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1160 → 1190
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1510 → 1802
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:1107 → 1331
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_036162489.1 → XP_036018382.1  protein TANC1 isoform X3

      UniProtKB/Swiss-Prot
      A2AUL4, A2AUL6, Q0VGY8, Q80VD2, Q8C0Q6
      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (5) summary
      PHA03095
      Location:903 → 1215
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1282 → 1413
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1289 → 1314
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1142 → 1172
      ANK; ANK repeat [structural motif]
      cl39094
      Location:1089 → 1313
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_036162492.1 → XP_036018385.1  protein TANC1 isoform X4

      UniProtKB/TrEMBL
      B9EJ77, E9QAF9
      Conserved Domains (5) summary
      PHA03095
      Location:896 → 1208
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1275 → 1406
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1282 → 1307
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1135 → 1165
      ANK; ANK repeat [structural motif]
      cl39094
      Location:1082 → 1306
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_006500037.5 → XP_006500100.1  protein TANC1 isoform X2

      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (6) summary
      PHA03095
      Location:914 → 1226
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1293 → 1424
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1300 → 1325
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1153 → 1183
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1503 → 1795
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:1100 → 1324
      Ank_2; Ankyrin repeats (3 copies)

    11. XM_017319204.3 → XP_017174693.1  protein TANC1 isoform X1

      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (6) summary
      PHA03095
      Location:921 → 1233
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1300 → 1431
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1307 → 1332
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1160 → 1190
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1510 → 1802
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:1107 → 1331
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_036162491.1 → XP_036018384.1  protein TANC1 isoform X4

      UniProtKB/TrEMBL
      B9EJ77, E9QAF9
      Conserved Domains (5) summary
      PHA03095
      Location:896 → 1208
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1275 → 1406
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1282 → 1307
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1135 → 1165
      ANK; ANK repeat [structural motif]
      cl39094
      Location:1082 → 1306
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_017319202.3 → XP_017174691.1  protein TANC1 isoform X1

      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (6) summary
      PHA03095
      Location:921 → 1233
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1300 → 1431
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1307 → 1332
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1160 → 1190
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1510 → 1802
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:1107 → 1331
      Ank_2; Ankyrin repeats (3 copies)

    14. XM_006500036.5 → XP_006500099.1  protein TANC1 isoform X1

      See identical proteins and their annotated locations for XP_006500099.1

      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (6) summary
      PHA03095
      Location:921 → 1233
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1300 → 1431
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1307 → 1332
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1160 → 1190
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1510 → 1802
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:1107 → 1331
      Ank_2; Ankyrin repeats (3 copies)

    15. XM_006500039.3 → XP_006500102.1  protein TANC1 isoform X5

      UniProtKB/TrEMBL
      B9EJ77
      Conserved Domains (6) summary
      PHA03095
      Location:703 → 1015
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1082 → 1213
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1089 → 1114
      TPR; TPR repeat [structural motif]
      sd00045
      Location:942 → 972
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1292 → 1584
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:889 → 1113
      Ank_2; Ankyrin repeats (3 copies)

    16. XM_006500040.5 → XP_006500103.1  protein TANC1 isoform X6

      UniProtKB/TrEMBL
      Q8CHA0
      Conserved Domains (6) summary
      PHA03095
      Location:599 → 911
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:978 → 1109
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:985 → 1010
      TPR; TPR repeat [structural motif]
      sd00045
      Location:838 → 868
      ANK; ANK repeat [structural motif]
      pfam09606
      Location:1188 → 1480
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl39094
      Location:785 → 1009
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VGY8.2 GenPept UniProtKB/Swiss-Prot:Q0VGY8

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