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    SECA2 Preprotein translocase SecA family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838767, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SECA2
    Official Full Name
    Preprotein translocase SecA family protein
    Primary source
    TAIR:AT1G21650
    Locus tag
    AT1G21650
    See related
    Araport:AT1G21650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F8K7.7; F8K7_7
    Summary
    Encodes a component of the thylakoid-localized Sec system involved in the translocation of cytoplasmic proteins into plastid. Loss-of-function mutations result in arrest at the globular stage and embryo lethality.
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    Genomic context

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    See SECA2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    37
    Sequence:
    Chromosome: 1; NC_003070.9 (7592664..7604229, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pumilio 20 Neighboring gene Calcium-binding EF hand family protein Neighboring gene NAD kinase 2 Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene Chaperone DnaJ-domain superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Putative Substrates of SEC2, a Chloroplast Inner Envelope Translocase. Li Y, et al. Plant Physiol, 2017 Apr. PMID 28213560, Free PMC Article
    2. Plastids contain a second sec translocase system with essential functions. Skalitzky CA, et al. Plant Physiol, 2011 Jan. PMID 21051552, Free PMC Article
    3. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001198129.1
    NM_001198130.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables chloroplast protein-transporting ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Preprotein translocase SecA family protein
    NP_001185058.1
    • Preprotein translocase SecA family protein; FUNCTIONS IN: ATPase activity, zinc ion binding, P-P-bond-hydrolysis-driven protein transmembrane transporter activity, ATP binding; INVOLVED IN: intracellular protein transport, protein targeting, protein transport by the Sec complex, protein import; LOCATED IN: internal side of plasma membrane, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), Zinc finger, RING-type (InterPro:IPR001841), SecA, preprotein translocase (InterPro:IPR022491), WD40 repeat (InterPro:IPR001680), SecA motor DEAD (InterPro:IPR014018), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), SecA Wing/Scaffold (InterPro:IPR011116), WD40-repeat-containing domain (InterPro:IPR017986), SecA preprotein, cross-linking domain (InterPro:IPR011130), SecA DEAD-like (InterPro:IPR011115), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), SecA conserved site (InterPro:IPR020937), WD40 repeat, subgroup (InterPro:IPR019781), SecA protein (InterPro:IPR000185); BEST Arabidopsis thaliana protein match is: zinc ion binding (TAIR:AT1G21651.1).
    NP_001185059.1
    • Preprotein translocase SecA family protein; FUNCTIONS IN: ATPase activity, P-P-bond-hydrolysis-driven protein transmembrane transporter activity, ATP binding; INVOLVED IN: intracellular protein transport, protein targeting, protein import, protein transport by the Sec complex; LOCATED IN: internal side of plasma membrane, chloroplast, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SecA Wing/Scaffold (InterPro:IPR011116), SecA preprotein, cross-linking domain (InterPro:IPR011130), SecA, preprotein translocase (InterPro:IPR022491), SecA DEAD-like (InterPro:IPR011115), SecA conserved site (InterPro:IPR020937), SecA motor DEAD (InterPro:IPR014018), SecA protein (InterPro:IPR000185); BEST Arabidopsis thaliana protein match is: Albino or Glassy Yellow 1 (TAIR:AT4G01800.1).
    NP_173584.5
    • Preprotein translocase SecA family protein; FUNCTIONS IN: ATPase activity, P-P-bond-hydrolysis-driven protein transmembrane transporter activity, ATP binding; INVOLVED IN: intracellular protein transport, protein targeting, protein transport by the Sec complex, protein import; LOCATED IN: internal side of plasma membrane, chloroplast, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SecA, preprotein translocase (InterPro:IPR022491), SecA motor DEAD (InterPro:IPR014018), SecA Wing/Scaffold (InterPro:IPR011116), SecA preprotein, cross-linking domain (InterPro:IPR011130), SecA conserved site (InterPro:IPR020937), SecA DEAD-like (InterPro:IPR011115), SecA protein (InterPro:IPR000185); BEST Arabidopsis thaliana protein match is: Albino or Glassy Yellow 1 (TAIR:AT4G01800.1); Has 21976 Blast hits to 13078 proteins in 2820 species: Archae - 0; Bacteria - 13647; Metazoa - 53; Fungi - 1; Plants - 97; Viruses - 0; Other Eukaryotes - 8178 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7592664..7604229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102014.6 → NP_173584.5  Preprotein translocase SecA family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173584.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WEE9
      Conserved Domains (5) summary
      PRK12904
      Location:75 → 1037
      PRK12904; preprotein translocase subunit SecA; Reviewed
      pfam01043
      Location:301 → 407
      SecA_PP_bind; SecA preprotein cross-linking domain
      pfam07516
      Location:770 → 1039
      SecA_SW; SecA Wing and Scaffold domain
      cl00947
      Location:77 → 149
      L-fuc_L-ara-isomerases; L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose ...
      cl21455
      Location:482 → 564
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001198129.1 → NP_001185058.1  Preprotein translocase SecA family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185058.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9VGN8, F4HY36
      Conserved Domains (8) summary
      COG2319
      Location:509 → 805
      WD40; WD40 repeat [General function prediction only]
      PRK12904
      Location:818 → 1791
      PRK12904; preprotein translocase subunit SecA; Reviewed
      pfam01043
      Location:1048 → 1154
      SecA_PP_bind; SecA preprotein cross-linking domain
      pfam07516
      Location:1517 → 1793
      SecA_SW; SecA Wing and Scaffold domain
      pfam14634
      Location:5 → 50
      zf-RING_5; zinc-RING finger domain
      sd00039
      Location:527 → 562
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:521 → 805
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl21455
      Location:1229 → 1311
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001198130.1 → NP_001185059.1  Preprotein translocase SecA family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185059.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D8WUA4, F4HY37, Q9XI14
      UniProtKB/TrEMBL
      A0A178WEE9
      Conserved Domains (5) summary
      PRK12904
      Location:75 → 1044
      PRK12904; preprotein translocase subunit SecA; Reviewed
      pfam01043
      Location:301 → 407
      SecA_PP_bind; SecA preprotein cross-linking domain
      pfam07516
      Location:770 → 1046
      SecA_SW; SecA Wing and Scaffold domain
      cl00947
      Location:77 → 149
      L-fuc_L-ara-isomerases; L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose ...
      cl21455
      Location:482 → 564
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D8WUA4.1

    Gene LinkOut

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