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    ODF2L outer dense fiber of sperm tails 2 like [ Homo sapiens (human) ]

    Gene ID: 57489, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ODF2Lprovided by HGNC
    Official Full Name
    outer dense fiber of sperm tails 2 likeprovided by HGNC
    Primary source
    HGNC:HGNC:29225
    See related
    Ensembl:ENSG00000122417 MIM:620130; AllianceGenome:HGNC:29225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Involved in negative regulation of cilium assembly. Located in centriolar satellite and ciliary basal body. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 2.6), lung (RPKM 2.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ODF2L in Genome Data Viewer
    Location:
    1p22.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (86346837..86396323, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (86186869..86236344, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (86812520..86862006, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2795 Neighboring gene uncharacterized LOC105378825 Neighboring gene microRNA 7856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1276 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:86875355-86875998 Neighboring gene RPL7L1 pseudogene 22 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_9486 Neighboring gene chloride channel accessory 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of BCAP, a new protein associated with basal bodies and centrioles. Ponsard C, et al. Front Biosci, 2007 May 1. PMID 17485331
    2. ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models. Li J, et al. J Clin Invest, 2023 Jan 17. PMID 36378528, Free PMC Article
    3. BCAP is a centriolar satellite protein and inhibitor of ciliogenesis. de Saram P, et al. J Cell Sci, 2017 Oct 1. PMID 28775150
    4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462
    5. Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins. Dho SE, et al. Sci Rep, 2019 Aug 28. PMID 31462741, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models.
      Title: ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1229, MGC111060

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cilium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein BCAP
    Names
    ODF2-like protein
    basal body centriole-associated protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007022.4 → NP_001007023.2  protein BCAP isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1, resulting in a protein (isoform b) that maintains the reading frame but is longer than isoform a.
      Source sequence(s)
      AC119749, AL136382
      Consensus CDS
      CCDS41354.2
      UniProtKB/Swiss-Prot
      A8MU56, B4E037, Q05C40, Q5BJG5, Q5TBX3, Q5TBX4, Q86X31, Q9ULJ1
      UniProtKB/TrEMBL
      B4DZ83
      Related
      ENSP00000359600.2, ENST00000359242.7
      Conserved Domains (1) summary
      COG1196
      Location:377 → 621
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001184765.2 → NP_001171694.1  protein BCAP isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform c) has a distinct C-terminus but is the same length as isoform a.
      Source sequence(s)
      AK303209, AL136382, BC047368, BC091490, BX499763, CD687053
      UniProtKB/TrEMBL
      B4DZ83
      Conserved Domains (2) summary
      COG1196
      Location:41 → 315
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:384 → 618
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. NM_001184766.2 → NP_001171695.1  protein BCAP isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform d) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK303209, AL136382, BC047368, BX499763, CD687053
      Consensus CDS
      CCDS53339.1
      UniProtKB/TrEMBL
      B4DZ83
      Related
      ENSP00000359597.2, ENST00000370566.7
      Conserved Domains (1) summary
      COG1196
      Location:243 → 543
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. NM_001366779.1 → NP_001353708.1  protein BCAP isoform e

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      H0YD68
      Conserved Domains (1) summary
      COG1196
      Location:192 → 495
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. NM_001366781.1 → NP_001353710.1  protein BCAP isoform f

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Consensus CDS
      CCDS90997.1
      UniProtKB/TrEMBL
      B4DZ83
      Related
      ENSP00000433092.2, ENST00000460698.7
      Conserved Domains (1) summary
      cl25732
      Location:323 → 626
      SMC_N; RecF/RecN/SMC N terminal domain

    6. NM_001366782.1 → NP_001353711.1  protein BCAP isoform e

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      H0YD68
      Conserved Domains (1) summary
      COG1196
      Location:192 → 495
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. NM_001366783.2 → NP_001353712.1  protein BCAP isoform g

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      B4DZ83
      Related
      ENSP00000512548.1, ENST00000696310.1
      Conserved Domains (1) summary
      cl25732
      Location:323 → 592
      SMC_N; RecF/RecN/SMC N terminal domain

    8. NM_001366784.1 → NP_001353713.1  protein BCAP isoform f

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Consensus CDS
      CCDS90997.1
      UniProtKB/TrEMBL
      B4DZ83
      Related
      ENSP00000512541.1, ENST00000696303.1
      Conserved Domains (1) summary
      cl25732
      Location:323 → 626
      SMC_N; RecF/RecN/SMC N terminal domain

    9. NM_001395519.1 → NP_001382448.1  protein BCAP isoform h

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      B4DZ83
      Conserved Domains (1) summary
      COG1196
      Location:284 → 587
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    10. NM_001395520.1 → NP_001382449.1  protein BCAP isoform h

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      B4DZ83
      Conserved Domains (1) summary
      COG1196
      Location:284 → 587
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. NM_001395521.1 → NP_001382450.1  protein BCAP isoform d

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Consensus CDS
      CCDS53339.1
      UniProtKB/TrEMBL
      B4DZ83
      Conserved Domains (1) summary
      COG1196
      Location:243 → 543
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    12. NM_001395522.1 → NP_001382451.1  protein BCAP isoform i

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      B4DZ83
      Conserved Domains (1) summary
      COG1196
      Location:243 → 543
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    13. NM_001395523.1 → NP_001382452.1  protein BCAP isoform j

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      B4DZ83
      Conserved Domains (1) summary
      COG1196
      Location:204 → 504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    14. NM_001395524.1 → NP_001382453.1  protein BCAP isoform j

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      B4DZ83
      Conserved Domains (1) summary
      COG1196
      Location:204 → 504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    15. NM_001395525.1 → NP_001382454.1  protein BCAP isoform e

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      H0YD68
      Conserved Domains (1) summary
      COG1196
      Location:192 → 495
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    16. NM_001395526.1 → NP_001382455.1  protein BCAP isoform e

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      H0YD68
      Related
      ENSP00000512542.1, ENST00000696304.1
      Conserved Domains (1) summary
      COG1196
      Location:192 → 495
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    17. NM_001395527.1 → NP_001382456.1  protein BCAP isoform e

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      H0YD68
      Conserved Domains (1) summary
      COG1196
      Location:192 → 495
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    18. NM_001395528.1 → NP_001382457.1  protein BCAP isoform e

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      H0YD68
      Conserved Domains (1) summary
      COG1196
      Location:192 → 495
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    19. NM_001395529.1 → NP_001382458.1  protein BCAP isoform k

      Status: VALIDATED

      Source sequence(s)
      AL136382
      UniProtKB/TrEMBL
      H0YD68
      Conserved Domains (2) summary
      COG1196
      Location:165 → 486
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:34 → 245
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    20. NM_001395530.1 → NP_001382459.1  protein BCAP isoform l

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      H0YD68
      Conserved Domains (2) summary
      TIGR02168
      Location:253 → 487
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:51 → 417
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    21. NM_001395531.1 → NP_001382460.1  protein BCAP isoform l

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      H0YD68
      Conserved Domains (2) summary
      TIGR02168
      Location:253 → 487
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:51 → 417
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    22. NM_001395532.1 → NP_001382461.1  protein BCAP isoform m

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      A0A8Q3SIE2
      Conserved Domains (1) summary
      COG1196
      Location:192 → 461
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    23. NM_001395533.1 → NP_001382462.1  protein BCAP isoform m

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      A0A8Q3SIE2
      Conserved Domains (1) summary
      COG1196
      Location:192 → 461
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    24. NM_001395534.1 → NP_001382463.1  protein BCAP isoform n

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Consensus CDS
      CCDS90996.1
      UniProtKB/TrEMBL
      A0A8Q3WMC5, H0YD68
      Related
      ENSP00000512536.1, ENST00000696297.1
      Conserved Domains (1) summary
      COG1196
      Location:112 → 412
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    25. NM_001395535.1 → NP_001382464.1  protein BCAP isoform n

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Consensus CDS
      CCDS90996.1
      UniProtKB/TrEMBL
      A0A8Q3WMC5, H0YD68
      Conserved Domains (1) summary
      COG1196
      Location:112 → 412
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    26. NM_001395536.1 → NP_001382465.1  protein BCAP isoform n

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Consensus CDS
      CCDS90996.1
      UniProtKB/TrEMBL
      A0A8Q3WMC5, H0YD68
      Conserved Domains (1) summary
      COG1196
      Location:112 → 412
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    27. NM_001395537.1 → NP_001382466.1  protein BCAP isoform n

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Consensus CDS
      CCDS90996.1
      UniProtKB/TrEMBL
      A0A8Q3WMC5, H0YD68
      Conserved Domains (1) summary
      COG1196
      Location:112 → 412
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    28. NM_001395538.1 → NP_001382467.1  protein BCAP isoform o

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      A0A8Q3SIE2
      Conserved Domains (1) summary
      COG1196
      Location:153 → 422
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    29. NM_001395539.1 → NP_001382468.1  protein BCAP isoform o

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      A0A8Q3SIE2
      Conserved Domains (1) summary
      COG1196
      Location:153 → 422
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    30. NM_001395540.1 → NP_001382469.1  protein BCAP isoform p

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      A0A8Q3SIE2
      Conserved Domains (1) summary
      COG1196
      Location:112 → 412
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    31. NM_001395541.1 → NP_001382470.1  protein BCAP isoform q

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      UniProtKB/TrEMBL
      H0YD68
      Conserved Domains (1) summary
      COG1196
      Location:73 → 373
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    32. NM_001395542.1 → NP_001382471.1  protein BCAP isoform r

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Conserved Domains (1) summary
      TIGR02168
      Location:79 → 392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    33. NM_001395543.1 → NP_001382472.1  protein BCAP isoform s

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Conserved Domains (1) summary
      COG1196
      Location:73 → 373
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    34. NM_001395544.1 → NP_001382473.1  protein BCAP isoform s

      Status: VALIDATED

      Source sequence(s)
      AC119749, AL136382
      Conserved Domains (1) summary
      COG1196
      Location:73 → 373
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    35. NM_020729.4 → NP_065780.2  protein BCAP isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC119749, AL136382
      Consensus CDS
      CCDS30763.2
      UniProtKB/TrEMBL
      B4DZ83
      Related
      ENSP00000294678.2, ENST00000294678.6
      Conserved Domains (1) summary
      cl23720
      Location:307 → 420
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      86346837..86396323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      86186869..86236344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULJ1.2 GenPept UniProtKB/Swiss-Prot:Q9ULJ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools