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    DIC2 dicarboxylate carrier 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828559, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DIC2
    Official Full Name
    dicarboxylate carrier 2
    Primary source
    TAIR:AT4G24570
    Locus tag
    AT4G24570
    See related
    Araport:AT4G24570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    dicarboxylate carrier 2; F22K18.230; F22K18_230
    Summary
    Encodes one of the mitochondrial dicarboxylate carriers (DIC): DIC1 (AT2G22500), DIC2 (AT4G24570), DIC3 (AT5G09470).
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    Genomic context

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    See DIC2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (12686459..12687650)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Clathrin adaptor complexes medium subunit family protein Neighboring gene ubiquitin-specific protease 16 Neighboring gene tRNA-Ser Neighboring gene Rho GTPase activation protein (RhoGAP) with PH domain-containing protein Neighboring gene RING finger protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The versatility of plant organic acid metabolism in leaves is underpinned by mitochondrial malate-citrate exchange. Lee CP, et al. Plant Cell, 2021 Dec 3. PMID 34498076, Free PMC Article
    2. Molecular identification of three Arabidopsis thaliana mitochondrial dicarboxylate carrier isoforms: organ distribution, bacterial expression, reconstitution into liposomes and functional characterization. Palmieri L, et al. Biochem J, 2008 Mar 15. PMID 18039180
    3. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202
    4. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. Lee TA, et al. Plant Cell, 2019 Nov. PMID 31519798, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The versatility of plant organic acid metabolism in leaves is underpinned by mitochondrial malate-citrate exchange.
      Title: The versatility of plant organic acid metabolism in leaves is underpinned by mitochondrial malate-citrate exchange.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118590.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dicarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within mitochondrial transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    dicarboxylate carrier 2
    NP_194188.1
    • dicarboxylate carrier 2 (DIC2); FUNCTIONS IN: binding, dicarboxylic acid transmembrane transporter activity; INVOLVED IN: transport, mitochondrial transport; LOCATED IN: mitochondrial inner membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Mitochondrial carrier protein (InterPro:IPR002067), Mitochondrial substrate carrier (InterPro:IPR001993), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: uncoupling protein 5 (TAIR:AT2G22500.1); Has 21371 Blast hits to 13123 proteins in 451 species: Archae - 0; Bacteria - 2; Metazoa - 8886; Fungi - 6458; Plants - 3905; Viruses - 0; Other Eukaryotes - 2120 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12686459..12687650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118590.2 → NP_194188.1  dicarboxylate carrier 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194188.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SB52
      UniProtKB/TrEMBL
      A0A178URN9, A0A5S9XVI0, C0Z2N8
      Conserved Domains (1) summary
      pfam00153
      Location:225 → 312
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SB52.1

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