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    Atp6v1c2 ATPase, H+ transporting, lysosomal V1 subunit C2 [ Mus musculus (house mouse) ]

    Gene ID: 68775, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atp6v1c2provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V1 subunit C2provided by MGI
    Primary source
    MGI:MGI:1916025
    See related
    Ensembl:ENSMUSG00000020566 AllianceGenome:MGI:1916025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110038G14Rik
    Summary
    Enables proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in positive regulation of Wnt signaling pathway. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is expressed in several structures, including alimentary system; nose; placenta; respiratory system; and yolk sac. Orthologous to human ATP6V1C2 (ATPase H+ transporting V1 subunit C2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 11.4), kidney adult (RPKM 6.5) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp6v1c2 in Genome Data Viewer
    Location:
    12 A1.1; 12 8.06 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17334722..17375700, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17284721..17325386, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31654 Neighboring gene predicted gene, 36568 Neighboring gene predicted gene 10054 Neighboring gene STARR-seq mESC enhancer starr_31655 Neighboring gene STARR-positive B cell enhancer mm9_chr12:17273043-17273344 Neighboring gene STARR-positive B cell enhancer ABC_E10741 Neighboring gene protein disulfide isomerase associated 6 Neighboring gene STARR-positive B cell enhancer ABC_E7124 Neighboring gene predicted gene, 46336 Neighboring gene nucleolar protein 10 Neighboring gene microRNA 3066

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung. Sun-Wada GH, et al. J Biol Chem, 2003 Nov 7. PMID 12947086
    2. Extra-renal locations of the a4 subunit of H(+)ATPase. Golder ZJ, et al. BMC Cell Biol, 2016 Jul 2. PMID 27368196, Free PMC Article
    3. Molecular architecture underlying fluid absorption by the developing inner ear. Honda K, et al. Elife, 2017 Oct 10. PMID 28994389, Free PMC Article
    4. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Sun-Wada GH, et al. Gene, 2003 Jan 2. PMID 12527205
    5. FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells. Jones MR, et al. Cell Mol Life Sci, 2022 Nov 29. PMID 36445537, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit C 2
    Names
    ATPase, H+ transporting, V1 subunit C
    V-ATPase subunit C 2
    vacuolar proton pump subunit C 2
    NP_001153104.1
    NP_598460.1
    XP_006515259.1
    XP_006515261.1
    XP_006515262.1
    XP_017170665.1
    XP_030102757.1
    XP_036013497.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159632.1 → NP_001153104.1  V-type proton ATPase subunit C 2 isoform 1

      See identical proteins and their annotated locations for NP_001153104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159815
      Consensus CDS
      CCDS49034.1
      UniProtKB/TrEMBL
      D3Z5W3
      Related
      ENSMUSP00000020884.10, ENSMUST00000020884.16
      Conserved Domains (2) summary
      cd14785
      Location:55 → 75
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:4 → 427
      V-ATPase_C; V-ATPase subunit C

    2. NM_133699.2 → NP_598460.1  V-type proton ATPase subunit C 2 isoform 2

      See identical proteins and their annotated locations for NP_598460.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC159815
      Consensus CDS
      CCDS25827.1
      UniProtKB/Swiss-Prot
      Q6PHA4, Q99L60
      UniProtKB/TrEMBL
      D3Z5W3
      Related
      ENSMUSP00000093500.6, ENSMUST00000095820.12
      Conserved Domains (2) summary
      cd14785
      Location:55 → 75
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 417
      V-ATPase_C; V-ATPase subunit C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      17334722..17375700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157604.1 → XP_036013497.1  V-type proton ATPase subunit C 2 isoform X2

      Conserved Domains (2) summary
      cd14785
      Location:55 → 75
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 381
      V-ATPase_C; V-ATPase subunit C

    2. XM_006515196.4 → XP_006515259.1  V-type proton ATPase subunit C 2 isoform X1

      See identical proteins and their annotated locations for XP_006515259.1

      UniProtKB/TrEMBL
      D3Z5W3
      Conserved Domains (2) summary
      cd14785
      Location:55 → 75
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:4 → 427
      V-ATPase_C; V-ATPase subunit C

    3. XM_006515199.4 → XP_006515262.1  V-type proton ATPase subunit C 2 isoform X3

      UniProtKB/TrEMBL
      D3Z5W3
      Related
      ENSMUSP00000152515.2, ENSMUST00000221129.2
      Conserved Domains (2) summary
      cd14785
      Location:55 → 75
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 371
      V-ATPase_C; V-ATPase subunit C

    4. XM_006515198.4 → XP_006515261.1  V-type proton ATPase subunit C 2 isoform X2

      Conserved Domains (2) summary
      cd14785
      Location:55 → 75
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 381
      V-ATPase_C; V-ATPase subunit C

    5. XM_030246897.1 → XP_030102757.1  V-type proton ATPase subunit C 2 isoform X5

      UniProtKB/TrEMBL
      D3Z5W3
      Conserved Domains (2) summary
      cd14785
      Location:60 → 86
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:1 → 311
      V-ATPase_C; V-ATPase subunit C

    6. XM_017315176.1 → XP_017170665.1  V-type proton ATPase subunit C 2 isoform X4

      UniProtKB/TrEMBL
      D3Z5W3
      Conserved Domains (2) summary
      cd14785
      Location:206 → 283
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:59 → 349
      V-ATPase_C; V-ATPase subunit C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99L60.1 GenPept UniProtKB/Swiss-Prot:Q99L60

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