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    Crebrf CREB3 regulatory factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303016, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Crebrfprovided by RGD
    Official Full Name
    CREB3 regulatory factorprovided by RGD
    Primary source
    RGD:1310862
    See related
    EnsemblRapid:ENSRNOG00000020769 AllianceGenome:RGD:1310862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310862
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of endoplasmic reticulum unfolded protein response; positive regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within maternal behavior; negative regulation of glucocorticoid mediated signaling pathway; and positive regulation of prolactin signaling pathway. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Orthologous to human CREBRF (CREB3 regulatory factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 227.9), Kidney (RPKM 225.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crebrf in Genome Data Viewer
    Location:
    10q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (16903607..16967450, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (16399170..16479650, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (16693846..16753162, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene NK2 homeobox 5 Neighboring gene BCL2 interacting protein 1 Neighboring gene uncharacterized LOC120095059 Neighboring gene ATPase H+ transporting V0 subunit e1 Neighboring gene ribosomal protein L26 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. Liang G, et al. Mol Cell Biol, 2006 Nov. PMID 16940180, Free PMC Article
    2. Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. Martyn AC, et al. Mol Cell Biol, 2012 Dec. PMID 23071095, Free PMC Article
    3. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. Audas TE, et al. Mol Cell Biol, 2008 Jun. PMID 18391022, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within maternal behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of glucocorticoid mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of glucocorticoid mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of prolactin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CREB3 regulatory factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277157.1 → NP_001264086.1  CREB3 regulatory factor

      See identical proteins and their annotated locations for NP_001264086.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K5W4, A6HDD8
      Related
      ENSRNOP00000073583.1, ENSRNOT00000079462.3
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      16903607..16967450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085888.2 → XP_038941816.1  CREB3 regulatory factor isoform X4

      UniProtKB/TrEMBL
      D4A811
      Related
      ENSRNOP00000104572.1, ENSRNOT00000153657.1
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    2. XM_017597237.3 → XP_017452726.1  CREB3 regulatory factor isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5W4, A6HDD8
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    3. XM_039085887.2 → XP_038941815.1  CREB3 regulatory factor isoform X3

      UniProtKB/TrEMBL
      A6HDD8
      Conserved Domains (1) summary
      cd14809
      Location:518 → 556
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    4. XM_063268953.1 → XP_063125023.1  CREB3 regulatory factor isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5W4

    5. XM_039085884.2 → XP_038941812.1  CREB3 regulatory factor isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5W4, A6HDD8
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    6. XM_063268955.1 → XP_063125025.1  CREB3 regulatory factor isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5W4

    7. XM_063268954.1 → XP_063125024.1  CREB3 regulatory factor isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5W4

    8. XM_039085886.2 → XP_038941814.1  CREB3 regulatory factor isoform X2

      UniProtKB/TrEMBL
      D4A811
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
    Nucleotide Protein Strain
    Heading Accession and Version

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