Rho rhodopsin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhoprovided by MGI
Official Full Name: rhodopsinprovided by MGI
Primary source: MGI:MGI:97914
See related: Ensembl:ENSMUSG00000030324 AllianceGenome:MGI:97914
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ops; RP4; Opn2; Noerg1
Summary: Predicted to enable 11-cis retinal binding activity; G protein-coupled photoreceptor activity; and spectrin binding activity. Involved in photoreceptor cell maintenance. Acts upstream of or within several processes, including podosome assembly; rod bipolar cell differentiation; and thermotaxis. Located in several cellular components, including rod photoreceptor outer segment; sperm head plasma membrane; and sperm midpiece. Is expressed in several structures, including brain; eye; and heart. Used to study congenital stationary night blindness autosomal dominant 1; retinitis pigmentosa; and retinitis pigmentosa 4. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Orthologous to human RHO (rhodopsin). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 53.72 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (115903741..115916999)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (115926754..115940038)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rhodopsin mislocalization drives ciliary dysregulation in a novel autosomal dominant retinitis pigmentosa knock-in mouse model.
Title: Rhodopsin mislocalization drives ciliary dysregulation in a novel autosomal dominant retinitis pigmentosa knock-in mouse model.
Light regulation of rhodopsin distribution during outer segment renewal in murine rod photoreceptors.
Title: Light regulation of rhodopsin distribution during outer segment renewal in murine rod photoreceptors.
Knockout and Replacement Gene Surgery to Treat Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa.
Title: Knockout and Replacement Gene Surgery to Treat Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa.
Aggregation of rhodopsin mutants in mouse models of autosomal dominant retinitis pigmentosa.
Title: Aggregation of rhodopsin mutants in mouse models of autosomal dominant retinitis pigmentosa.
Super-resolution mapping in rod photoreceptors identifies rhodopsin trafficking through the inner segment plasma membrane as an essential subcellular pathway.
Title: Super-resolution mapping in rod photoreceptors identifies rhodopsin trafficking through the inner segment plasma membrane as an essential subcellular pathway.
Microglia Preserve Visual Function in a Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant.
Title: Microglia Preserve Visual Function in a Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant.
Rho enhancers play unexpectedly minor roles in Rhodopsin transcription and rod cell integrity.
Title: Rho enhancers play unexpectedly minor roles in Rhodopsin transcription and rod cell integrity.
Maintenance of optogenetic channel rhodopsin (ChR2) function in aging mice: Implications for pharmacological studies of inhibitory synaptic transmission, quantal content, and calcium homeostasis.
Title: Maintenance of optogenetic channel rhodopsin (ChR2) function in aging mice: Implications for pharmacological studies of inhibitory synaptic transmission, quantal content, and calcium homeostasis.
Structural abnormalities of retinal pigment epithelial cells in a light-inducible, rhodopsin mutant mouse.
Title: Structural abnormalities of retinal pigment epithelial cells in a light-inducible, rhodopsin mutant mouse.
Investigating the Role of Rhodopsin F45L Mutation in Mouse Rod Photoreceptor Signaling and Survival.
Title: Investigating the Role of Rhodopsin F45L Mutation in Mouse Rod Photoreceptor Signaling and Survival.

Submit: New GeneRIF Correction See all GeneRIFs (78)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (6) 1 citation
Endonuclease-mediated (4) 1 citation
Targeted (16) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rho (e-PCR), detects polymorphism
- UniSTS:265743

PMC17675P2 (e-PCR)
- UniSTS:271644

Rho (e-PCR), detects polymorphism
- UniSTS:468014

Rho (e-PCR), detects polymorphism
- UniSTS:255284

M55171 (e-PCR)
- UniSTS:159561

D6Mit44 (e-PCR), detects polymorphism
- UniSTS:130950

Rho (e-PCR), detects polymorphism
- UniSTS:536463

BB282502 (e-PCR)
- UniSTS:208018

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 11-cis retinal binding	ISS Inferred from Sequence or Structural Similarity more info
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled photoreceptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables retinal binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opsin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled opsin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in absorption of visible light	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of temperature stimulus involved in thermoception	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within podosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in red, far-red light phototransduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to light intensity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rod bipolar cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thermotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor disc membrane	ISO Inferred from Sequence Orthology more info
located_in photoreceptor disc membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info	PubMed
located_in photoreceptor inner segment membrane	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info	PubMed
located_in photoreceptor outer segment membrane	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in rod photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sperm head plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rhodopsin

Names: L opsin; LWS opsin; long wavelength sensitive opsin; opsin 2; red opsin; rod opsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145383.2 → NP_663358.1 rhodopsin

See identical proteins and their annotated locations for NP_663358.1

Status: VALIDATED

Source sequence(s)

AC142099, AK044333, AK164314, BC013125

Consensus CDS

CCDS20446.1

UniProtKB/Swiss-Prot

P15409, Q8K0D8, Q96DZ2

Related

ENSMUSP00000032471.7, ENSMUST00000032471.9

Conserved Domains (2) summary

pfam10413
Location:3 → 37

Rhodopsin_N; Amino terminal of the G-protein receptor rhodopsin

cd15080
Location:38 → 317

7tmA_MWS_opsin; medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

115903741..115916999

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505861.3 → XP_006505924.1 rhodopsin isoform X2

Conserved Domains (2) summary

pfam10413
Location:7 → 27

Rhodopsin_N; Amino terminal of the G-protein receptor rhodopsin

cd15080
Location:28 → 307

7tmA_MWS_opsin; medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017321493.1 → XP_017176982.1 rhodopsin isoform X3

Conserved Domains (1) summary

cd15080
Location:1 → 279

7tmA_MWS_opsin; medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006505860.2 → XP_006505923.1 rhodopsin isoform X1

Conserved Domains (2) summary

pfam10413
Location:10 → 33

Rhodopsin_N; Amino terminal of the G-protein receptor rhodopsin

cd15080
Location:34 → 313

7tmA_MWS_opsin; medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors