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    Rbm33 RNA binding motif protein 33 [ Mus musculus (house mouse) ]

    Gene ID: 381626, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Rbm33provided by MGI
    Official Full Name
    RNA binding motif protein 33provided by MGI
    Primary source
    MGI:MGI:1919670
    See related
    Ensembl:ENSMUSG00000048271 AllianceGenome:MGI:1919670
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prr8; 3200001K10Rik; 6430512A10Rik
    Summary
    Predicted to enable N6-methyladenosine-containing RNA reader activity and lncRNA binding activity. Predicted to be involved in RNA export from nucleus and regulation of mRNA stability. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in head; limb; and trunk. Orthologous to human RBM33 (RNA binding motif protein 33). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 22.3), CNS E14 (RPKM 16.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbm33 in Genome Data Viewer
    Location:
    5 B1; 5 14.36 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (28521817..28624242)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (28316836..28419244)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12715 Neighboring gene canopy FGF signaling regulator 1 Neighboring gene STARR-seq mESC enhancer starr_12716 Neighboring gene predicted gene, 35524 Neighboring gene predicted gene, 35602 Neighboring gene STARR-seq mESC enhancer starr_12719 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:28729422-28729605 Neighboring gene STARR-seq mESC enhancer starr_12720 Neighboring gene STARR-seq mESC enhancer starr_12721 Neighboring gene RIKEN cDNA 9530036O11Rik Neighboring gene sonic hedgehog brain enhancer region in intron 2 Neighboring gene sonic hedgehog Neighboring gene sonic hedgehog floor plate enhancer 1 Neighboring gene STARR-seq mESC enhancer starr_12722 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury. Zhang Y, et al. Clin Hemorheol Microcirc, 2023. PMID 37927249
    2. The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances. Symmons O, et al. Dev Cell, 2016 Dec 5. PMID 27867070, Free PMC Article
    3. Mapping the Shh long-range regulatory domain. Anderson E, et al. Development, 2014 Oct. PMID 25252942, Free PMC Article
    4. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
    5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury.
      Title: CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N6-methyladenosine-containing RNA reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N6-methyladenosine-containing RNA reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lncRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lncRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 33
    Names
    proline rich 8
    proline-rich protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028234.1 → NP_082510.1  RNA-binding protein 33

      See identical proteins and their annotated locations for NP_082510.1

      Status: PROVISIONAL

      Source sequence(s)
      AC134530, AK014289, AK153360, BB637766, CB528202, CN703034
      Consensus CDS
      CCDS51448.1
      UniProtKB/Swiss-Prot
      Q3U5Z3, Q8C5J6, Q9CXK9
      Related
      ENSMUSP00000062449.7, ENSMUST00000059644.13
      Conserved Domains (1) summary
      cd00590
      Location:1161 → 1226
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      28521817..28624242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535733.5 → XP_006535796.1  RNA-binding protein 33 isoform X1

      Conserved Domains (5) summary
      PHA03418
      Location:451 → 491
      PHA03418; hypothetical E4 protein; Provisional
      COG5271
      Location:15 → 238
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK09510
      Location:802 → 873
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      PRK14086
      Location:456 → 618
      dnaA; chromosomal replication initiator protein DnaA
      cd00590
      Location:1160 → 1225
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_006535734.5 → XP_006535797.1  RNA-binding protein 33 isoform X2

      UniProtKB/TrEMBL
      D3Z5I9
      Related
      ENSMUSP00000110534.2, ENSMUST00000114884.8
      Conserved Domains (6) summary
      PHA03418
      Location:411 → 451
      PHA03418; hypothetical E4 protein; Provisional
      PHA03247
      Location:398 → 688
      PHA03247; large tegument protein UL36; Provisional
      COG5271
      Location:15 → 200
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK09510
      Location:762 → 833
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      cd00590
      Location:1121 → 1186
      RRM_SF; RNA recognition motif (RRM) superfamily
      pfam09770
      Location:417 → 538
      PAT1; Topoisomerase II-associated protein PAT1

    3. XM_006535735.5 → XP_006535798.1  RNA-binding protein 33 isoform X3

      Conserved Domains (6) summary
      PHA03418
      Location:411 → 451
      PHA03418; hypothetical E4 protein; Provisional
      PHA03247
      Location:398 → 688
      PHA03247; large tegument protein UL36; Provisional
      COG5271
      Location:15 → 200
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK09510
      Location:762 → 833
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      cd00590
      Location:1120 → 1185
      RRM_SF; RNA recognition motif (RRM) superfamily
      pfam09770
      Location:417 → 538
      PAT1; Topoisomerase II-associated protein PAT1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXK9.2 GenPept UniProtKB/Swiss-Prot:Q9CXK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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