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    Klf6 Kruppel-like transcription factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 23849, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Klf6provided by MGI
    Official Full Name
    Kruppel-like transcription factor 6provided by MGI
    Primary source
    MGI:MGI:1346318
    See related
    Ensembl:ENSMUSG00000000078 AllianceGenome:MGI:1346318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FM2; FM6; Zf9; BCD1; CPBP; Copeb; Ierepo1; Ierepo3
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of connective tissue replacement. Acts upstream of or within cytokine-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and peripheral nervous system. Human ortholog(s) of this gene implicated in prostate cancer and stomach cancer. Orthologous to human KLF6 (KLF transcription factor 6). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 23.3), bladder adult (RPKM 19.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klf6 in Genome Data Viewer
    Location:
    13 A1; 13 2.94 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (5911488..5920392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (5861489..5870393)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33546 Neighboring gene RIKEN cDNA 1700016G22 gene Neighboring gene STARR-seq mESC enhancer starr_33549 Neighboring gene predicted gene, 35464 Neighboring gene STARR-positive B cell enhancer ABC_E1867 Neighboring gene STARR-seq mESC enhancer starr_33553 Neighboring gene predicted gene, 46401 Neighboring gene STARR-seq mESC enhancer starr_33554 Neighboring gene STARR-seq mESC enhancer starr_33556 Neighboring gene STARR-seq mESC enhancer starr_33558 Neighboring gene predicted gene, 35615

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The zinc-finger transcription factor KLF6 regulates cardiac fibrosis. Li N, et al. Life Sci, 2024 Aug 15. PMID 38851422
    2. Krüppel-like factor 6 regulates mitochondrial function in the kidney. Mallipattu SK, et al. J Clin Invest, 2015 Mar 2. PMID 25689250, Free PMC Article
    3. Krüppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene. Trucco LD, et al. FASEB J, 2014 Dec. PMID 25212220
    4. Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury. Ghiassi-Nejad Z, et al. Hepatology, 2013 Feb. PMID 22961688, Free PMC Article
    5. Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation. Tarocchi M, et al. Hepatology, 2011 Aug. PMID 21563203, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The zinc-finger transcription factor KLF6 regulates cardiac fibrosis.
      Title: The zinc-finger transcription factor KLF6 regulates cardiac fibrosis.
    2. miRNA-21 promotes the progression of acute liver failure via the KLF6/autophagy/IL-23 signaling pathway.
      Title: miRNA‑21 promotes the progression of acute liver failure via the KLF6/autophagy/IL‑23 signaling pathway.
    3. Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development.
      Title: Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development.
    4. MicroRNA-22-3p in human umbilical cord mesenchymal stem cell-secreted exosomes inhibits granulosa cell apoptosis by targeting KLF6 and ATF4-ATF3-CHOP pathway in POF mice.
      Title: MicroRNA-22-3p in human umbilical cord mesenchymal stem cell-secreted exosomes inhibits granulosa cell apoptosis by targeting KLF6 and ATF4-ATF3-CHOP pathway in POF mice.
    5. KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagy.
      Title: KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagy.
    6. Identification of KLF6/PSGs and NPY-Related USF2/CEACAM Transcriptional Regulatory Networks via Spinal Cord Bulk and Single-Cell RNA-Seq Analysis.
      Title: Identification of KLF6/PSGs and NPY-Related USF2/CEACAM Transcriptional Regulatory Networks via Spinal Cord Bulk and Single-Cell RNA-Seq Analysis.
    7. Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis.
      Title: Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis.
    8. Kruppel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humans.
      Title: Krüppel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humans.
    9. Hepatocyte KLF6 expression affects FXR signalling and the clinical course of primary sclerosing cholangitis.
      Title: Hepatocyte KLF6 expression affects FXR signalling and the clinical course of primary sclerosing cholangitis.
    10. Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras.
      Title: Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of connective tissue replacement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Krueppel-like factor 6
    Names
    Kruppel-like factor 6
    core promoter element binding protein
    immediate early response, erythropoietin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011803.2 → NP_035933.2  Krueppel-like factor 6

      See identical proteins and their annotated locations for NP_035933.2

      Status: VALIDATED

      Source sequence(s)
      AK146615, BY128594
      Consensus CDS
      CCDS26229.1
      UniProtKB/TrEMBL
      Q3UGJ1, Q8BPQ2, Q8VDZ7
      Related
      ENSMUSP00000000080.7, ENSMUST00000000080.8
      Conserved Domains (4) summary
      COG5048
      Location:212 → 300
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240 → 259
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:235 → 259
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:281 → 306
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      5911488..5920392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08584.3 GenPept UniProtKB/Swiss-Prot:O08584

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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