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    Slc37a3 solute carrier family 37 (glycerol-3-phosphate transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 72144, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slc37a3provided by MGI
    Official Full Name
    solute carrier family 37 (glycerol-3-phosphate transporter), member 3provided by MGI
    Primary source
    MGI:MGI:1919394
    See related
    Ensembl:ENSMUSG00000029924 AllianceGenome:MGI:1919394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610507O21Rik
    Summary
    Enables xenobiotic transmembrane transporter activity. Involved in xenobiotic transmembrane transport. Located in lysosomal membrane. Orthologous to human SLC37A3 (solute carrier family 37 member 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 8.6), CNS E18 (RPKM 8.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc37a3 in Genome Data Viewer
    Location:
    6 B1; 6 18.11 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39311704..39354659, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39334770..39377725, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34147 Neighboring gene predicted gene, 53067 Neighboring gene predicted gene, 26008 Neighboring gene STARR-seq mESC enhancer starr_15634 Neighboring gene STARR-seq mESC enhancer starr_15635 Neighboring gene STARR-seq mESC enhancer starr_15639 Neighboring gene STARR-positive B cell enhancer ABC_E4822 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:39329756-39330023 Neighboring gene RAB19, member RAS oncogene family Neighboring gene makorin, ring finger protein, 1 Neighboring gene STARR-seq mESC enhancer starr_15648 Neighboring gene predicted gene 10244

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Yu Z, et al. Elife, 2018 May 10. PMID 29745899, Free PMC Article
    2. Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene. Amson RB, et al. Proc Natl Acad Sci U S A, 1996 Apr 30. PMID 8632996, Free PMC Article
    3. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, et al. Genomics, 2004 Nov. PMID 15475267
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106297

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in xenobiotic transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sugar phosphate exchanger 3
    Names
    solute carrier family 37 member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361617.1 → NP_001348546.1  sugar phosphate exchanger 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC153624
      Consensus CDS
      CCDS20020.1
      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      UniProtKB/TrEMBL
      A0A0R4J133
      Conserved Domains (1) summary
      cd17342
      Location:20 → 476
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    2. NM_001361618.1 → NP_001348547.1  sugar phosphate exchanger 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC153624
      Consensus CDS
      CCDS20020.1
      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      UniProtKB/TrEMBL
      A0A0R4J133
      Conserved Domains (1) summary
      cd17342
      Location:20 → 476
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    3. NM_001361619.1 → NP_001348548.1  sugar phosphate exchanger 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC153624
      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cl27298
      Location:114 → 462
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    4. NM_028123.3 → NP_082399.3  sugar phosphate exchanger 3 isoform a

      See identical proteins and their annotated locations for NP_082399.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC153624, AK076213, CJ161523
      Consensus CDS
      CCDS20020.1
      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      UniProtKB/TrEMBL
      A0A0R4J133
      Related
      ENSMUSP00000087709.5, ENSMUST00000090243.8
      Conserved Domains (1) summary
      cd17342
      Location:20 → 476
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    RNA

    1. NR_155076.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC153624

    2. NR_155077.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC153624

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39311704..39354659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506658.3 → XP_006506721.1  sugar phosphate exchanger 3 isoform X1

      See identical proteins and their annotated locations for XP_006506721.1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    2. XM_006506665.3 → XP_006506728.1  sugar phosphate exchanger 3 isoform X1

      See identical proteins and their annotated locations for XP_006506728.1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    3. XM_006506661.4 → XP_006506724.1  sugar phosphate exchanger 3 isoform X1

      See identical proteins and their annotated locations for XP_006506724.1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    4. XM_006506659.4 → XP_006506722.1  sugar phosphate exchanger 3 isoform X1

      See identical proteins and their annotated locations for XP_006506722.1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    5. XM_036152320.1 → XP_036008213.1  sugar phosphate exchanger 3 isoform X2

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      UniProtKB/TrEMBL
      A0A0R4J133
      Conserved Domains (1) summary
      cd17342
      Location:20 → 476
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    6. XM_017321757.1 → XP_017177246.1  sugar phosphate exchanger 3 isoform X2

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      UniProtKB/TrEMBL
      A0A0R4J133
      Conserved Domains (1) summary
      cd17342
      Location:20 → 476
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    7. XM_006506663.5 → XP_006506726.1  sugar phosphate exchanger 3 isoform X1

      See identical proteins and their annotated locations for XP_006506726.1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    8. XM_030255602.1 → XP_030111462.1  sugar phosphate exchanger 3 isoform X2

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      UniProtKB/TrEMBL
      A0A0R4J133
      Conserved Domains (1) summary
      cd17342
      Location:20 → 476
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    9. XM_006506666.4 → XP_006506729.1  sugar phosphate exchanger 3 isoform X1

      See identical proteins and their annotated locations for XP_006506729.1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    10. XM_036152319.1 → XP_036008212.1  sugar phosphate exchanger 3 isoform X1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    11. XM_006506667.4 → XP_006506730.1  sugar phosphate exchanger 3 isoform X1

      See identical proteins and their annotated locations for XP_006506730.1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    12. XM_006506664.4 → XP_006506727.1  sugar phosphate exchanger 3 isoform X1

      See identical proteins and their annotated locations for XP_006506727.1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    13. XM_030255601.1 → XP_030111461.1  sugar phosphate exchanger 3 isoform X1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    14. XM_036152318.1 → XP_036008211.1  sugar phosphate exchanger 3 isoform X1

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      Conserved Domains (1) summary
      cd17342
      Location:20 → 468
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters

    15. XM_017321758.2 → XP_017177247.1  sugar phosphate exchanger 3 isoform X2

      UniProtKB/Swiss-Prot
      Q3TIT8, Q4FZD9, Q8BVX2
      UniProtKB/TrEMBL
      A0A0R4J133
      Conserved Domains (1) summary
      cd17342
      Location:20 → 476
      MFS_SLC37A3; Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TIT8.1 GenPept UniProtKB/Swiss-Prot:Q3TIT8

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