ADRA2C adrenoceptor alpha 2C [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADRA2Cprovided by HGNC
Official Full Name: adrenoceptor alpha 2Cprovided by HGNC
Primary source: HGNC:HGNC:283
See related: Ensembl:ENSG00000184160 MIM:104250; AllianceGenome:HGNC:283
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 4p16.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (3766385..3768526)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (3765283..3767445)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (3768112..3770253)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.
Title: Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.
alpha2A- and alpha2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.
Title: α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.
Prognostic significance of alpha- and beta2-adrenoceptor gene expression in breast cancer patients.
Title: Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients.
High alpha2-Adrenergic Receptor expression is associated with Pathogenesis of Preeclampsia and Fetal Growth Restriction.
Title: Human Placenta Expresses α(2)-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction.
alpha2A- and alpha2C-adrenoceptors are functional receptors for norepinephrine, dopamine, and other previously assumed selective D2-like receptor ligands.
Title: α(2A)- and α(2C)-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands.
The frequency of alpha2CDel322-325-AR in suicide and non-suicide victims was similar. Genotype frequencies for the alpha2CDel322-325-AR polymorphism in depressed and schizophrenic subjects were higher than in controls, but these differences did not reach statistical significance. The results indicate that alpha2CDel322-325-AR may play a role in the pathophysiology of opiate abuse and dependence.
Title: Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence.
Immunoreactivity for ADRA2C was densely distributed in vascular smooth muscle of nasal turbinates.
Title: Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.
ADRA2c is associated with heart rate recovery after exercise.
Title: Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.
Common polymorphisms in the ADRA2C gene are not associated with orthostatic hypotension risk in Chinese.
Title: Association between Common Genetic Variants of α2A-, α2B-, and α2C-Adrenergic Receptors and Orthostatic Hypotension.
Adrenergic receptor genotype influences heart failure severity and beta-blocker response in children with dilated cardiomyopathy.
Title: Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4S3282 (e-PCR)
- UniSTS:75023

NoName (e-PCR)
- UniSTS:483109

STS-J03853 (e-PCR)
- UniSTS:13513

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables alpha-2A adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha2-adrenergic receptor activity	EXP Inferred from Experiment more info	PubMed
enables alpha2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables epinephrine binding	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of protein kinase B activity	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adrenergic receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of epinephrine secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of insulin secretion	TAS Traceable Author Statement more info
involved_in negative regulation of norepinephrine secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of norepinephrine secretion	TAS Traceable Author Statement more info	PubMed
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor transactivation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: alpha-2C adrenergic receptor

Names: adrenergic, alpha-2C-, receptor; alpha-2 adrenergic receptor subtype C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR; alpha2-AR-C4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012640.1 RefSeqGene

Range

4817..6958

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000683.4 → NP_000674.2 alpha-2C adrenergic receptor

See identical proteins and their annotated locations for NP_000674.2

Status: REVIEWED

Source sequence(s)

AC141928

Consensus CDS

CCDS47004.1

UniProtKB/Swiss-Prot

P18825, P35369, Q9HB49

UniProtKB/TrEMBL

Q4W594

Related

ENSP00000386069.2, ENST00000330055.7

Conserved Domains (1) summary

cd15323
Location:60 → 448

7tmA_alpha2C_AR; alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors