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    Dhrs4 dehydrogenase/reductase 4 [ Mus musculus (house mouse) ]

    Gene ID: 28200, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Dhrs4provided by MGI
    Official Full Name
    dehydrogenase/reductase 4provided by MGI
    Primary source
    MGI:MGI:90169
    See related
    Ensembl:ENSMUSG00000022210 AllianceGenome:MGI:90169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CR; RRD; NDRD; PHCR; PSCD; mouNRDR; D14Ucla2
    Summary
    Enables retinal dehydrogenase activity. Acts upstream of or within retinal metabolic process. Located in mitochondrion and peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 28.9), liver E18 (RPKM 24.8) and 28 other tissues See more
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    Genomic context

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    See Dhrs4 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55715880..55727797)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55478741..55490340)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52145 Neighboring gene STARR-positive B cell enhancer ABC_E5438 Neighboring gene STARR-seq mESC enhancer starr_36769 Neighboring gene predicted gene, 41158 Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene copine VI

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate. Lei Z, et al. Biochemistry, 2003 Apr 15. PMID 12680773
    2. Bioinformatic identification and characterization of new members of short-chain dehydrogenase/reductase superfamily. Keller B, et al. Mol Cell Endocrinol, 2006 Mar 27. PMID 16406282
    3. CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription. Su Z, et al. Genet Mol Res, 2016 Jun 3. PMID 27323117
    4. Proteomic analysis of SET-binding proteins. Vera J, et al. Proteomics, 2007 Feb. PMID 17309103
    5. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. Gabrielli F, et al. Gene, 2012 Dec 15. PMID 23036705

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An analysis of the relationship between the promoter characteristics and RNA expression of the DHRS4 gene cluster indicated that the development of CpG islands, in addition to the promoter sequence, during mammalian evolution could modulate the dose compensatory regulation of the copy number-varied DHRS4 gene cluster
      Title: CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.
    2. M. musculus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. M. musculus genes are orthologs of human DHRS2 and DHRS4 genes respectively.
      Title: Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-keto sterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-keto sterol reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonyl reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbonyl reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinal dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular ketone metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 4
    Names
    NADPH-dependent carbonyl reductase
    NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
    NADPH-dependent retinol dehydrogenase/reductase
    dehydrogenase/reductase (SDR family) member 4
    peroxisomal short-chain alcohol dehydrogenase
    short chain dehydrogenase/reductase family 25C member 2
    NP_001033027.2
    NP_109611.1
    XP_030103712.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037938.2 → NP_001033027.2  dehydrogenase/reductase SDR family member 4 isoform 1

      See identical proteins and their annotated locations for NP_001033027.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159002, AK146988, BQ032668, BY291911
      Consensus CDS
      CCDS27111.1
      UniProtKB/Swiss-Prot
      G3X8V7, Q99LB2, Q9EQU4
      UniProtKB/TrEMBL
      Q3UIB5
      Related
      ENSMUSP00000022821.7, ENSMUST00000022821.8
      Conserved Domains (2) summary
      cd08936
      Location:24 → 279
      CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR
      PRK07231
      Location:31 → 274
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional

    2. NM_030686.2 → NP_109611.1  dehydrogenase/reductase SDR family member 4 isoform 2

      See identical proteins and their annotated locations for NP_109611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC159002, AK018788, AW125533, BY291911
      Consensus CDS
      CCDS88668.1
      UniProtKB/TrEMBL
      Q9D2U3
      Related
      ENSMUSP00000154481.2, ENSMUST00000226168.2
      Conserved Domains (1) summary
      cl21454
      Location:24 → 178
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55715880..55727797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247852.2 → XP_030103712.1  dehydrogenase/reductase SDR family member 4 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:24 → 137
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LB2.3 GenPept UniProtKB/Swiss-Prot:Q99LB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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