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    Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano [ Mus musculus (house mouse) ]

    Gene ID: 14910, updated on 5-Nov-2024

    Summary

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    Official Symbol
    Gt(ROSA)26Sorprovided by MGI
    Official Full Name
    gene trap ROSA 26, Philippe Sorianoprovided by MGI
    Primary source
    MGI:MGI:104735
    See related
    Ensembl:ENSMUSG00000086429 AllianceGenome:MGI:104735
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R26; ROSA26; Gtrgeo26; Gtrosa26; Thumpd3as1
    Summary
    This gene produces a long non-coding RNA (lncRNA) that is under the control of a constitutive promoter. This locus is a widely used site for the integration of transgenes and reporter constructs. [provided by RefSeq, Oct 2015]
    Expression
    Ubiquitous expression in bladder adult (RPKM 11.4), liver E14 (RPKM 10.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gt(ROSA)26Sor in Genome Data Viewer
    Location:
    6 E3; 6 52.73 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113044389..113054205, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113067428..113077244, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4853 Neighboring gene predicted gene, 43868 Neighboring gene THUMP domain containing 3 Neighboring gene predicted gene, 22591 Neighboring gene STARR-seq mESC enhancer starr_17032 Neighboring gene STARR-seq mESC enhancer starr_17033 Neighboring gene SET domain containing 5 Neighboring gene lipoma HMGIC fusion partner-like protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Bonaventura J, et al. Nat Commun, 2019 Oct 11. PMID 31604917, Free PMC Article
    2. Sublamina-specific organization of the blood brain barrier in the mouse olfactory nerve layer. Beiersdorfer A, et al. Glia, 2020 Mar. PMID 31696993
    3. Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons. McGregor MM, et al. Cell Rep, 2019 Nov 5. PMID 31693884, Free PMC Article
    4. Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization. Fowlkes JL, et al. Bone, 2020 Jan. PMID 31689526, Free PMC Article
    5. Dynamic Changes in Ultrastructure of the Primary Cilium in Migrating Neuroblasts in the Postnatal Brain. Matsumoto M, et al. J Neurosci, 2019 Dec 11. PMID 31685650, Free PMC Article

    See all (1000) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial TRPV4 channels in lung edema and injury.
      Title: Endothelial TRPV4 channels in lung edema and injury.
    2. Study shows SETD5-AS1 is highly expressed in the ischemia-reperfusion injury model. SETD5-AS1 participates in the development of ischemic stroke by activating PTEN and inhibiting PI3K/AKT pathway
      Title: SETD5-AS1 stimulates neuron death in stroke via promoting PTEN expression.
    3. Used a ROSA-flox-stop-flox-EYFP reporter mouse to assay the expression patterns of Cre recombinase side-by-side in thirteen myeloid-Cre strains by flow cytometry.
      Title: Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice.
    4. When injected with tamoxifen, adult NEX-CreERT2 mice induced reporter gene expression exclusively in projection neurons of the neocortex and hippocampus.
      Title: In vivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 mice.
    5. The endogenous Rosa26 promoter was silenced and several ubiquitous (pCAG, EF1alpha and CMV) and tissue-specific (VeCad, alphaSMA) promoters in the modRosa26 locus in vivo, characterized.
      Title: A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters.
    6. Data show a dramatic discrepancy between ROSA26 reporter activity and Pdgfrb promoter driven Cre dependent myc-tagged Cthrc1 transgene expression.
      Title: Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries.
    7. Results demonstrated that 70-75% of the fibroblasts generated from Dll1-msd Cre, ROSA26-rtTA embryos possess Cre recombinase activity.
      Title: Generation of transgenic mice expressing Cre recombinase under the control of the Dll1 mesoderm enhancer element.
    8. The ROSA26 LacZ-neo(R) insertion confers resistance to mammary tumors in Apc(Min/+) mice
      Title: The ROSA26 LacZ-neo(R) insertion confers resistance to mammary tumors in Apc(Min/+) mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Other Names

    • beta geo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027008.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      BQ032740, BY207362, U83174
      Related
      ENSMUST00000124246.6

    2. NR_027009.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site near the 5' end, compared to variant 1.
      Source sequence(s)
      AC155722, BQ032740, BY207362
      Related
      ENSMUST00000159544.5

    3. NR_027010.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' and 3' splice pattern, compared to variant 1.
      Source sequence(s)
      AK021028, BY207362, BY727583

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113044389..113054205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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