Neurl2 neuralized E3 ubiquitin protein ligase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Neurl2provided by MGI
Official Full Name: neuralized E3 ubiquitin protein ligase 2provided by MGI
Primary source: MGI:MGI:3043305
See related: Ensembl:ENSMUSG00000039873 AllianceGenome:MGI:3043305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ozz; Neur2; Ozz-E3
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within sarcomere organization. Located in muscle tendon junction. Part of VCB complex. Is expressed in forebrain; gonad; metanephros; and submandibular gland. Orthologous to human NEURL2 (neuralized E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 18.2), ovary adult (RPKM 15.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.27 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164672650..164675516, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164830730..164833596, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neur1 and Neur2 are required for hippocampus-dependent spatial memory and synaptic plasticity.
Title: Neur1 and Neur2 are required for hippocampus-dependent spatial memory and synaptic plasticity.
the Ozz-E3 ligase regulates Alix at sites where the actin cytoskeleton undergoes remodeling.
Title: Alix protein is substrate of Ozz-E3 ligase and modulates actin remodeling in skeletal muscle.
Ozz-E3 is the ubiquitin ligase complex that interacts with and regulates myosin within its fully assembled cytoskeletal structure
Title: Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development.
Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1
Title: Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of VCB complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in muscle tendon junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuralized-like protein 2

Names: neuralized-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082974.2 → NP_001076443.1 neuralized-like protein 2

See identical proteins and their annotated locations for NP_001076443.1

Status: VALIDATED

Source sequence(s)

AL591495

Consensus CDS

CCDS38330.1

UniProtKB/Swiss-Prot

Q9D0S4

UniProtKB/TrEMBL

A2A5J5

Related

ENSMUSP00000041806.5, ENSMUST00000042775.5

Conserved Domains (2) summary

smart00969
Location:249 → 285

SOCS_box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases

cd12887
Location:25 → 242

SPRY_NHR_like; SPRY domain in neuralized homology repeat