ctdsp2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctdsp2provided by ZNC
Official Full Name: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-184
See related: Ensembl:ENSDARG00000036102 AllianceGenome:ZFIN:ZDB-GENE-030131-184
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb16c04; zgc:77714; wu:fb16c04
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within neuron differentiation. Is expressed in brain; eye; fin; integument; and muscle. Orthologous to human CTDSP2 (CTD small phosphatase 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (24669039..24682198, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (24742498..24755955, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Generation of mature miR-26b is activated during neurogenesis, where it suppresses Ctdsp2 protein expression and is required for neuronal cell differentiation in vivo
Title: Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

NP_955838.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199544.1 → NP_955838.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

See identical proteins and their annotated locations for NP_955838.1

Status: PROVISIONAL

Source sequence(s)

BC063974

UniProtKB/TrEMBL

A0A8M1P9L4, Q6P3I6

Related

ENSDARP00000094810.3, ENSDART00000104035.4

Conserved Domains (2) summary

COG5190
Location:64 → 253

FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]

TIGR02251
Location:88 → 247

HIF-SF_euk; Dullard-like phosphatase domain