lemd3 LEM domain containing 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lemd3provided by ZNC
Official Full Name: LEM domain containing 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-490
See related: Ensembl:ENSDARG00000015824 AllianceGenome:ZFIN:ZDB-GENE-030131-490
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7158446; wu:fb34b12; si:dkey-6a5.6
Summary: Predicted to enable chromatin DNA binding activity. Acts upstream of or within cerebellum vasculature development. Predicted to be located in nuclear inner membrane. Predicted to be integral component of membrane. Predicted to be integral component of nuclear inner membrane. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome. Orthologous to human LEMD3 (LEM domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (12917164..12930016, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (12918315..12931167, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellum vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inner nuclear membrane protein Man1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044864.1 → NP_001038329.1 inner nuclear membrane protein Man1

See identical proteins and their annotated locations for NP_001038329.1

Status: PROVISIONAL

Source sequence(s)

BX119963

UniProtKB/TrEMBL

B5DE27, Q5TZH9

Related

ENSDARP00000005474.7, ENSDART00000013604.8

Conserved Domains (3) summary

cd12942
Location:2 → 45

LEM_Man1; LEM (Lap2/Emerin/Man1) domain found in inner nuclear membrane protein Man1

cd12286
Location:714 → 805

RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins

pfam09402
Location:462 → 676

MSC; Man1-Src1p-C-terminal domain