Sord sorbitol dehydrogenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sordprovided by MGI
Official Full Name: sorbitol dehydrogenaseprovided by MGI
Primary source: MGI:MGI:98266
See related: Ensembl:ENSMUSG00000027227 AllianceGenome:MGI:98266
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SDH; XDH; Sdh1; Sdh-1; Sodh-1
Summary: Enables D-sorbitol dehydrogenase (acceptor) activity; D-xylulose reductase activity; and L-iditol 2-dehydrogenase (NAD+) activity. Involved in D-glucuronate catabolic process to D-xylulose 5-phosphate; flagellated sperm motility; and fructose biosynthetic process. Acts upstream of or within sorbitol metabolic process. Located in mitochondrion and motile cilium. Is active in cytosol. Is expressed in several structures, including alimentary system; early embryo; limb; metanephros; and nervous system. Used to study cataract. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 335.8), kidney adult (RPKM 231.0) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.59 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (122065320..122095818)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (122234839..122265337)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

flavonoids induced marked improvement in paw licking time, paw edema %, malondialdehyde content, superoxide dismutase, and sorbitol dehydrogenase activities, with slight progress in paw interlukin-1beta. Additionally, silymarin augmented brain content of dopamine and norepinephrine.
Title: Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity.
Nicotine-induced reduced expression of Sord could be involved in impaired secretory functions of the epididymis.
Title: Protein profile screening: reduced expression of Sord in the mouse epididymis induced by nicotine inhibits tyrosine phosphorylation level in capacitated spermatozoa.
Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
Title: Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
Title: ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.
Knockout mice had the highest sorbitol content among various genetic types including mice wwith human aldose reductase.
Title: Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Spontaneous (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234510

NoName (e-PCR)
- UniSTS:547147

Sord (e-PCR), detects polymorphism
- UniSTS:547147

G36383 (e-PCR)
- UniSTS:44529

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-sorbitol dehydrogenase (acceptor) activity	IDA Inferred from Direct Assay more info	PubMed
enables D-sorbitol dehydrogenase (acceptor) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables D-xylulose reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables D-xylulose reductase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables L-iditol 2-dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-iditol 2-dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-iditol 2-dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-iditol 2-dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate	IDA Inferred from Direct Assay more info	PubMed
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fructose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in sorbitol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sorbitol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in sorbitol catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sorbitol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xylitol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in xylitol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xylitol metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sorbitol dehydrogenase

Names: L-iditol 2-dehydrogenase; polyol dehydrogenase; sorbitol dehydrogenase 1; xylitol dehydrogenase

NP_666238.1

EC 1.1.1.14

EC 1.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.