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    Kctd15 potassium channel tetramerisation domain containing 15 [ Mus musculus (house mouse) ]

    Gene ID: 233107, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kctd15provided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 15provided by MGI
    Primary source
    MGI:MGI:2385276
    See related
    Ensembl:ENSMUSG00000030499 AllianceGenome:MGI:2385276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including adrenal gland; esophagus; hemolymphoid system gland; nervous system; and respiratory system. Orthologous to human KCTD15 (potassium channel tetramerization domain containing 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 20.1), CNS E14 (RPKM 19.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kctd15 in Genome Data Viewer
    Location:
    7 B1- B2; 7 20.41 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (34336424..34354934, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34636999..34655509, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12784 Neighboring gene STARR-seq mESC enhancer starr_18597 Neighboring gene STARR-seq mESC enhancer starr_18598 Neighboring gene predicted gene, 35378 Neighboring gene STARR-seq mESC enhancer starr_18604 Neighboring gene predicted gene, 57783 Neighboring gene predicted gene 12781

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The BTB-containing protein Kctd15 is SUMOylated in vivo. Zarelli VE, et al. PLoS One, 2013. PMID 24086424, Free PMC Article
    2. Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster. Williams MJ, et al. PLoS Genet, 2014 Sep. PMID 25187989, Free PMC Article
    3. KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis. Raymundo JR, et al. J Clin Invest, 2023 Dec 19. PMID 38113115, Free PMC Article
    4. The essential player in adipogenesis GRP78 is a novel KCTD15 interactor. Smaldone G, et al. Int J Biol Macromol, 2018 Aug. PMID 29665387
    5. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the physiological role played by the complex KCTD15-GRP78 in the adipogenesis
      Title: The essential player in adipogenesis GRP78 is a novel KCTD15 interactor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25497

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD15
    Names
    potassium channel tetramerization domain-containing protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360818.2 → NP_001347747.1  BTB/POZ domain-containing protein KCTD15

      Status: VALIDATED

      Source sequence(s)
      BX649462
      Consensus CDS
      CCDS21141.1
      UniProtKB/Swiss-Prot
      Q8K0E1
      Related
      ENSMUSP00000032709.2, ENSMUST00000032709.3
      Conserved Domains (1) summary
      cd18388
      Location:55 → 153
      BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

    2. NM_001360820.2 → NP_001347749.1  BTB/POZ domain-containing protein KCTD15

      Status: VALIDATED

      Source sequence(s)
      BX649462
      Consensus CDS
      CCDS21141.1
      UniProtKB/Swiss-Prot
      Q8K0E1
      Related
      ENSMUSP00000103704.2, ENSMUST00000108069.8
      Conserved Domains (1) summary
      cd18388
      Location:55 → 153
      BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

    3. NM_001420858.1 → NP_001407787.1  BTB/POZ domain-containing protein KCTD15

      Status: VALIDATED

      Source sequence(s)
      BX649462
      UniProtKB/Swiss-Prot
      Q8K0E1

    4. NM_001420859.1 → NP_001407788.1  BTB/POZ domain-containing protein KCTD15

      Status: VALIDATED

      Source sequence(s)
      BX649462
      UniProtKB/Swiss-Prot
      Q8K0E1

    5. NM_001420860.1 → NP_001407789.1  BTB/POZ domain-containing protein KCTD15

      Status: VALIDATED

      Source sequence(s)
      BX649462
      UniProtKB/Swiss-Prot
      Q8K0E1

    6. NM_146188.2 → NP_666300.1  BTB/POZ domain-containing protein KCTD15

      See identical proteins and their annotated locations for NP_666300.1

      Status: VALIDATED

      Source sequence(s)
      AW124009, BC031749, BX649462
      Consensus CDS
      CCDS21141.1
      UniProtKB/Swiss-Prot
      Q8K0E1
      Related
      ENSMUSP00000103705.3, ENSMUST00000108070.9
      Conserved Domains (1) summary
      cd18388
      Location:55 → 153
      BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      34336424..34354934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539905.3 → XP_006539968.1  BTB/POZ domain-containing protein KCTD15 isoform X1

      See identical proteins and their annotated locations for XP_006539968.1

      UniProtKB/Swiss-Prot
      Q8K0E1
      Conserved Domains (1) summary
      cd18388
      Location:55 → 153
      BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

    2. XM_006539904.5 → XP_006539967.1  BTB/POZ domain-containing protein KCTD15 isoform X1

      See identical proteins and their annotated locations for XP_006539967.1

      UniProtKB/Swiss-Prot
      Q8K0E1
      Conserved Domains (1) summary
      cd18388
      Location:55 → 153
      BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

    3. XM_006539901.5 → XP_006539964.1  BTB/POZ domain-containing protein KCTD15 isoform X1

      See identical proteins and their annotated locations for XP_006539964.1

      UniProtKB/Swiss-Prot
      Q8K0E1
      Conserved Domains (1) summary
      cd18388
      Location:55 → 153
      BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0E1.1 GenPept UniProtKB/Swiss-Prot:Q8K0E1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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