Hunk hormonally upregulated Neu-associated kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hunkprovided by RGD
Official Full Name: hormonally upregulated Neu-associated kinaseprovided by RGD
Primary source: RGD:1565091
See related: EnsemblRapid:ENSRNOG00000002092 AllianceGenome:RGD:1565091
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565091
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human HUNK (hormonally up-regulated Neu-associated kinase). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Brain (RPKM 17.3), Lung (RPKM 17.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (43127244..43244502)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (29641122..29758392)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (30550141..30663465)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hunk (e-PCR), detects polymorphism
- UniSTS:259089

BF400669 (e-PCR)
- UniSTS:245015

D11Got20 (e-PCR)
- UniSTS:114720

D11Got24 (e-PCR)
- UniSTS:112013

d11rat75 (e-PCR)
- UniSTS:120792

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hormonally up-regulated neu tumor-associated kinase

NP_001178591.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191662.2 → NP_001178591.1 hormonally up-regulated neu tumor-associated kinase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I5ZV60, D4A7Q7

Related

ENSRNOP00000083012.1, ENSRNOT00000099297.2

Conserved Domains (1) summary

cd14070
Location:58 → 320

STKc_HUNK; Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V)